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Immune Related Genes Underpin the Evolution of Adaptive Immunity in Jawless Vertebrates

The study of immune related genes in lampreys and hagfish provides a unique perspective on the evolutionary genetic underpinnings of adaptive immunity and the evolution of vertebrate genomes. Separated from their jawed cousins at the stem of the vertebrate lineage, these jawless vertebrates have man...

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Autores principales: McCurley, Nathanael, Hirano, Masayuki, Das, Sabyasachi, Cooper, Max D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308329/
https://www.ncbi.nlm.nih.gov/pubmed/23024600
http://dx.doi.org/10.2174/138920212799860670
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author McCurley, Nathanael
Hirano, Masayuki
Das, Sabyasachi
Cooper, Max D
author_facet McCurley, Nathanael
Hirano, Masayuki
Das, Sabyasachi
Cooper, Max D
author_sort McCurley, Nathanael
collection PubMed
description The study of immune related genes in lampreys and hagfish provides a unique perspective on the evolutionary genetic underpinnings of adaptive immunity and the evolution of vertebrate genomes. Separated from their jawed cousins at the stem of the vertebrate lineage, these jawless vertebrates have many of the gene families and gene regulatory networks associated with the defining morphological and physiological features of vertebrates. These include genes vital for innate immunity, inflammation, wound healing, protein degradation, and the development, signaling and trafficking of lymphocytes. Jawless vertebrates recognize antigen by using leucine-rich repeat (LRR) based variable lymphocyte receptors (VLRs), which are very different from the immunoglobulin (Ig) based T cell receptor (TCR) and B cell receptor (BCR) used for antigen recognition by jawed vertebrates. The somatically constructed VLR genes are expressed in monoallelic fashion by T-like and B-like lymphocytes. Jawless and jawed vertebrates thus share many of the genes that provide the molecular infrastructure and physiological context for adaptive immune responses, yet use entirely different genes and mechanisms of combinatorial assembly to generate diverse repertoires of antigen recognition receptors.
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spelling pubmed-33083292012-10-01 Immune Related Genes Underpin the Evolution of Adaptive Immunity in Jawless Vertebrates McCurley, Nathanael Hirano, Masayuki Das, Sabyasachi Cooper, Max D Curr Genomics Article The study of immune related genes in lampreys and hagfish provides a unique perspective on the evolutionary genetic underpinnings of adaptive immunity and the evolution of vertebrate genomes. Separated from their jawed cousins at the stem of the vertebrate lineage, these jawless vertebrates have many of the gene families and gene regulatory networks associated with the defining morphological and physiological features of vertebrates. These include genes vital for innate immunity, inflammation, wound healing, protein degradation, and the development, signaling and trafficking of lymphocytes. Jawless vertebrates recognize antigen by using leucine-rich repeat (LRR) based variable lymphocyte receptors (VLRs), which are very different from the immunoglobulin (Ig) based T cell receptor (TCR) and B cell receptor (BCR) used for antigen recognition by jawed vertebrates. The somatically constructed VLR genes are expressed in monoallelic fashion by T-like and B-like lymphocytes. Jawless and jawed vertebrates thus share many of the genes that provide the molecular infrastructure and physiological context for adaptive immune responses, yet use entirely different genes and mechanisms of combinatorial assembly to generate diverse repertoires of antigen recognition receptors. Bentham Science Publishers 2012-04 2012-04 /pmc/articles/PMC3308329/ /pubmed/23024600 http://dx.doi.org/10.2174/138920212799860670 Text en ©2012 Bentham Science Publishers http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
McCurley, Nathanael
Hirano, Masayuki
Das, Sabyasachi
Cooper, Max D
Immune Related Genes Underpin the Evolution of Adaptive Immunity in Jawless Vertebrates
title Immune Related Genes Underpin the Evolution of Adaptive Immunity in Jawless Vertebrates
title_full Immune Related Genes Underpin the Evolution of Adaptive Immunity in Jawless Vertebrates
title_fullStr Immune Related Genes Underpin the Evolution of Adaptive Immunity in Jawless Vertebrates
title_full_unstemmed Immune Related Genes Underpin the Evolution of Adaptive Immunity in Jawless Vertebrates
title_short Immune Related Genes Underpin the Evolution of Adaptive Immunity in Jawless Vertebrates
title_sort immune related genes underpin the evolution of adaptive immunity in jawless vertebrates
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308329/
https://www.ncbi.nlm.nih.gov/pubmed/23024600
http://dx.doi.org/10.2174/138920212799860670
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