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The RNA-binding protein Staufen1 is increased in DM1 skeletal muscle and promotes alternative pre-mRNA splicing

In myotonic dystrophy type 1 (DM1), dystrophia myotonica protein kinase messenger ribonucleic acids (RNAs; mRNAs) with expanded CUG repeats (CUG(exp)) aggregate in the nucleus and become toxic to cells by sequestering and/or misregulating RNA-binding proteins, resulting in aberrant alternative splic...

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Detalles Bibliográficos
Autores principales:	Ravel-Chapuis, Aymeric, Bélanger, Guy, Yadava, Ramesh S., Mahadevan, Mani S., DesGroseillers, Luc, Côté, Jocelyn, Jasmin, Bernard J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308689/ https://www.ncbi.nlm.nih.gov/pubmed/22431750 http://dx.doi.org/10.1083/jcb.201108113

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