The evolution of metazoan extracellular matrix

The modular domain structure of extracellular matrix (ECM) proteins and their genes has allowed extensive exon/domain shuffling during evolution to generate hundreds of ECM proteins. Many of these arose early during metazoan evolution and have been highly conserved ever since. Others have undergone...

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Detalles Bibliográficos
Autor principal: Hynes, Richard O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308698/
https://www.ncbi.nlm.nih.gov/pubmed/22431747
http://dx.doi.org/10.1083/jcb.201109041
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author Hynes, Richard O.
author_facet Hynes, Richard O.
author_sort Hynes, Richard O.
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description The modular domain structure of extracellular matrix (ECM) proteins and their genes has allowed extensive exon/domain shuffling during evolution to generate hundreds of ECM proteins. Many of these arose early during metazoan evolution and have been highly conserved ever since. Others have undergone duplication and divergence during evolution, and novel combinations of domains have evolved to generate new ECM proteins, particularly in the vertebrate lineage. The recent sequencing of several genomes has revealed many details of this conservation and evolution of ECM proteins to serve diverse functions in metazoa.
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spelling pubmed-33086982012-09-19 The evolution of metazoan extracellular matrix Hynes, Richard O. J Cell Biol Reviews The modular domain structure of extracellular matrix (ECM) proteins and their genes has allowed extensive exon/domain shuffling during evolution to generate hundreds of ECM proteins. Many of these arose early during metazoan evolution and have been highly conserved ever since. Others have undergone duplication and divergence during evolution, and novel combinations of domains have evolved to generate new ECM proteins, particularly in the vertebrate lineage. The recent sequencing of several genomes has revealed many details of this conservation and evolution of ECM proteins to serve diverse functions in metazoa. The Rockefeller University Press 2012-03-19 /pmc/articles/PMC3308698/ /pubmed/22431747 http://dx.doi.org/10.1083/jcb.201109041 Text en © 2012 Hynes This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Hynes, Richard O.
The evolution of metazoan extracellular matrix
title The evolution of metazoan extracellular matrix
title_full The evolution of metazoan extracellular matrix
title_fullStr The evolution of metazoan extracellular matrix
title_full_unstemmed The evolution of metazoan extracellular matrix
title_short The evolution of metazoan extracellular matrix
title_sort evolution of metazoan extracellular matrix
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308698/
https://www.ncbi.nlm.nih.gov/pubmed/22431747
http://dx.doi.org/10.1083/jcb.201109041
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