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Mapping Structural Determinants within Third Intracellular Loop That Direct Signaling Specificity of Type 1 Corticotropin-releasing Hormone Receptor

The type 1 corticotropin-releasing hormone receptor (CRH-R1) influences biological responses important for adaptation to stressful stimuli, through activation of multiple downstream effectors. The structural motifs within CRH-R1 that mediate G protein activation and signaling selectivity are unknown...

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Detalles Bibliográficos
Autores principales:	Punn, Anu, Chen, Jing, Delidaki, Maria, Tang, Jiyou, Liapakis, George, Lehnert, Hendrik, Levine, Michael A., Grammatopoulos, Dimitris K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2012
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308756/ https://www.ncbi.nlm.nih.gov/pubmed/22247544 http://dx.doi.org/10.1074/jbc.M111.272161

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