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High Fidelity Processing and Activation of the Human α-Defensin HNP1 Precursor by Neutrophil Elastase and Proteinase 3

The azurophilic granules of human neutrophils contain four α-defensins called human neutrophil peptides (HNPs 1–4). HNPs are tridisulfide-linked antimicrobial peptides involved in the intracellular killing of organisms phagocytosed by neutrophils. The peptides are produced as inactive precursors (pr...

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Detalles Bibliográficos
Autores principales:	Tongaonkar, Prasad, Golji, Amir E., Tran, Patti, Ouellette, André J., Selsted, Michael E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308943/ https://www.ncbi.nlm.nih.gov/pubmed/22448222 http://dx.doi.org/10.1371/journal.pone.0032469

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