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Daf-2 Signaling Modifies Mutant SOD1 Toxicity in C. elegans

The DAF-2 Insulin/IGF-1 signaling (IIS) pathway is a strong modifier of Caenorhabditis elegans longevity and healthspan. As aging is the greatest risk factor for developing neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS), we were interested in determining if DAF-2 signaling mo...

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Detalles Bibliográficos
Autores principales:	Boccitto, Marco, Lamitina, Todd, Kalb, Robert G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308959/ https://www.ncbi.nlm.nih.gov/pubmed/22457769 http://dx.doi.org/10.1371/journal.pone.0033494

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