Cargando…

Deleterious GRM1 Mutations in Schizophrenia

We analysed a phenotypically well-characterised sample of 450 schziophrenia patients and 605 controls for rare non-synonymous single nucleotide polymorphisms (nsSNPs) in the GRM1 gene, their functional effects and family segregation. GRM1 encodes the metabotropic glutamate receptor 1 (mGluR1), whose...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ayoub, Mohammed Akli, Angelicheva, Dora, Vile, David, Chandler, David, Morar, Bharti, Cavanaugh, Juleen A., Visscher, Peter M., Jablensky, Assen, Pfleger, Kevin D. G., Kalaydjieva, Luba
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308973/ https://www.ncbi.nlm.nih.gov/pubmed/22448230 http://dx.doi.org/10.1371/journal.pone.0032849

Ejemplares similares

Integrity of genome-wide genotype data from low passage lymphoblastoid cell lines
por: McCarthy, Nina S., et al.
Publicado: (2016)

The stretcher spontaneous neurodegenerative mutation models Charcot-Marie-Tooth disease type 4D
por: Chandler, David, et al.
Publicado: (2013)

The diagnostic concept of schizophrenia: its history, evolution, and future prospects
por: Jablensky, Assen
Publicado: (2010)

No evidence for association between polymorphisms in GRM3 and schizophrenia
por: Norton, Nadine, et al.
Publicado: (2005)

The role of group II metabotropic glutamate receptors in cognition and anxiety: Comparative studies in GRM2(−/−), GRM3(−/−) and GRM2/3(−/−) knockout mice
por: De Filippis, Bianca, et al.
Publicado: (2015)

Variants of GRM7 as risk factor and response to antipsychotic therapy in schizophrenia
por: Liang, Wei, et al.
Publicado: (2020)

Chemical Modulation of Mutant mGlu(1) Receptors Derived from Deleterious GRM1 Mutations Found in Schizophrenics
por: Cho, Hyekyung P., et al.
Publicado: (2014)

Altered hippocampal expression of glutamate receptors and transporters in GRM2 and GRM3 knockout mice
por: Lyon, Louisa, et al.
Publicado: (2008)

Congenital Cataracts – Facial Dysmorphism – Neuropathy
por: Kalaydjieva, Luba
Publicado: (2006)

Meta-analysis supports GWAS-implicated link between GRM3 and schizophrenia risk
por: Saini, S M, et al.
Publicado: (2017)

Deficits in Agency in Schizophrenia, and Additional Deficits in Body Image, Body Schema, and Internal Timing, in Passivity Symptoms
por: Graham, Kyran T., et al.
Publicado: (2014)

Genetic studies of the Roma (Gypsies): a review
por: Kalaydjieva, Luba, et al.
Publicado: (2001)

What Did the WHO Studies Really Find?
por: Jablensky, Assen, et al.
Publicado: (2008)

Analysis of Schizophrenia Data Using A Nonlinear Threshold Index Logistic Model
por: Jiang, Zhenyu, et al.
Publicado: (2014)

Profiling Epidermal Growth Factor Receptor and Heregulin Receptor 3 Heteromerization Using Receptor Tyrosine Kinase Heteromer Investigation Technology
por: Ayoub, Mohammed Akli, et al.
Publicado: (2013)

Characterization of Three Vasopressin Receptor 2 Variants: An Apparent Polymorphism (V266A) and Two Loss-of-Function Mutations (R181C and M311V)
por: Armstrong, Stephen P., et al.
Publicado: (2013)

circ-Grm1 promotes pulmonary artery smooth muscle cell proliferation and migration via suppression of GRM1 expression by FUS
por: Sun, Shijing, et al.
Publicado: (2021)

Pseudodominant inheritance of autosomal recessive congenital stationary night blindness in one family with three co‐segregating deleterious GRM6 variants identified by next‐generation sequencing
por: Liu, Hong‐Yan, et al.
Publicado: (2019)

The functional GRM3 Kozak sequence variant rs148754219 affects the risk of schizophrenia and alcohol dependence as well as bipolar disorder
por: O’Brien, Niamh L., et al.
Publicado: (2014)

Sequence variations of GRM6 in patients with high myopia
por: Xu, Xiaoyu, et al.
Publicado: (2009)

Cognitive Impairment and Brain Imaging Characteristics of Patients with Congenital Cataracts, Facial Dysmorphism, Neuropathy Syndrome
por: Chamova, Teodora, et al.
Publicado: (2015)

mGlu5 Receptor Functional Interactions and Addiction
por: Brown, Robyn M., et al.
Publicado: (2012)

Dominant Mutations in GRM1 Cause Spinocerebellar Ataxia Type 44
por: Watson, Lauren M., et al.
Publicado: (2017)

Dominant Mutations in GRM1 Cause Spinocerebellar Ataxia Type 44
por: Watson, Lauren M., et al.
Publicado: (2017)

Dominant Mutations in GRM1 Cause Spinocerebellar Ataxia Type 44
por: Watson, Lauren M., et al.
Publicado: (2017)

Cellular and cytokine-dependent immunosuppressive mechanisms of grm1-transgenic murine melanoma
por: Alb, Miriam, et al.
Publicado: (2012)

Biallelic GRM7 variants cause epilepsy, microcephaly, and cerebral atrophy
por: Marafi, Dana, et al.
Publicado: (2020)

No Association Between GRM3 and Japanese Methamphetamine-Induced Psychosis
por: Tsunoka, Tomoko, et al.
Publicado: (2011)

The role of rs2237781 within GRM8 in eating behavior
por: Gast, Marie-Therese, et al.
Publicado: (2013)

GRM7 Regulates Embryonic Neurogenesis via CREB and YAP
por: Xia, Wenlong, et al.
Publicado: (2015)

T249. THE ROYAL AUSTRALIAN AND NEW ZEALAND CLINICAL PRACTICE GUIDELINES FOR SCHIZOPHRENIA AND RELATED DISORDERS (2016) – A STEP TOWARDS BETTER CARE?
por: Galletly, Cherrie, et al.
Publicado: (2018)

Loss-of-Function Models of the Metabotropic Glutamate Receptor Genes Grm8a and Grm8b Display Distinct Behavioral Phenotypes in Zebrafish Larvae (Danio rerio)
por: Lüffe, Teresa M., et al.
Publicado: (2022)

Use of schizophrenia and bipolar disorder polygenic risk scores to identify psychotic disorders
por: Calafato, Maria Stella, et al.
Publicado: (2018)

Metabotropic Glutamate Receptor 1 (Grm1) Is An Oncogene In Epithelial Cells
por: Martino, Jeffrey J, et al.
Publicado: (2012)

Encapsulation mechanisms and structural studies of GRM2 bacterial microcompartment particles
por: Kalnins, Gints, et al.
Publicado: (2020)

A Geophysical Remediation Monitoring Method Selection Tool (GRM‐MST)
por: Thompson, Joshua, et al.
Publicado: (2022)

Novel Pharmacology Following Heteromerization of the Angiotensin II Type 2 Receptor and the Bradykinin Type 2 Receptor
por: Johnstone, Elizabeth K. M., et al.
Publicado: (2022)

Genome-wide burden of deleterious coding variants increased in schizophrenia
por: Loohuis, Loes M. Olde, et al.
Publicado: (2015)

To Explore the Mechanism of the GRM4 Gene in Osteosarcoma by RNA Sequencing and Bioinformatics Approach
por: Pang, Yunguo, et al.
Publicado: (2018)

Correlation between variants of the CREB1 and GRM7 genes and risk of depression
por: Wang, Li, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_85na1gcbdsjk1lq6qpf9lg43oo