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Mutation Accumulation in a Selfing Population: Consequences of Different Mutation Rates between Selfers and Outcrossers
Currently existing theories predict that because deleterious mutations accumulate at a higher rate, selfing populations suffer from more intense genetic degradation relative to outcrossing populations. This prediction may not always be true when we consider a potential difference in deleterious muta...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308984/ https://www.ncbi.nlm.nih.gov/pubmed/22448251 http://dx.doi.org/10.1371/journal.pone.0033541 |
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author | Nakayama, Shin-Ichiro Shi, Shoi Tateno, Masaki Shimada, Masakazu Takahasi, K. Ryo |
author_facet | Nakayama, Shin-Ichiro Shi, Shoi Tateno, Masaki Shimada, Masakazu Takahasi, K. Ryo |
author_sort | Nakayama, Shin-Ichiro |
collection | PubMed |
description | Currently existing theories predict that because deleterious mutations accumulate at a higher rate, selfing populations suffer from more intense genetic degradation relative to outcrossing populations. This prediction may not always be true when we consider a potential difference in deleterious mutation rate between selfers and outcrossers. By analyzing the evolutionary stability of selfing and outcrossing in an infinite population, we found that the genome-wide deleterious mutation rate would be lower in selfing than in outcrossing organisms. When this difference in mutation rate was included in simulations, we found that in a small population, mutations accumulated more slowly under selfing rather than outcrossing. This result suggests that under frequent and intense bottlenecks, a selfing population may have a lower risk of genetic extinction than an outcrossing population. |
format | Online Article Text |
id | pubmed-3308984 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-33089842012-03-23 Mutation Accumulation in a Selfing Population: Consequences of Different Mutation Rates between Selfers and Outcrossers Nakayama, Shin-Ichiro Shi, Shoi Tateno, Masaki Shimada, Masakazu Takahasi, K. Ryo PLoS One Research Article Currently existing theories predict that because deleterious mutations accumulate at a higher rate, selfing populations suffer from more intense genetic degradation relative to outcrossing populations. This prediction may not always be true when we consider a potential difference in deleterious mutation rate between selfers and outcrossers. By analyzing the evolutionary stability of selfing and outcrossing in an infinite population, we found that the genome-wide deleterious mutation rate would be lower in selfing than in outcrossing organisms. When this difference in mutation rate was included in simulations, we found that in a small population, mutations accumulated more slowly under selfing rather than outcrossing. This result suggests that under frequent and intense bottlenecks, a selfing population may have a lower risk of genetic extinction than an outcrossing population. Public Library of Science 2012-03-20 /pmc/articles/PMC3308984/ /pubmed/22448251 http://dx.doi.org/10.1371/journal.pone.0033541 Text en Nakayama et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Nakayama, Shin-Ichiro Shi, Shoi Tateno, Masaki Shimada, Masakazu Takahasi, K. Ryo Mutation Accumulation in a Selfing Population: Consequences of Different Mutation Rates between Selfers and Outcrossers |
title | Mutation Accumulation in a Selfing Population: Consequences of Different Mutation Rates between Selfers and Outcrossers |
title_full | Mutation Accumulation in a Selfing Population: Consequences of Different Mutation Rates between Selfers and Outcrossers |
title_fullStr | Mutation Accumulation in a Selfing Population: Consequences of Different Mutation Rates between Selfers and Outcrossers |
title_full_unstemmed | Mutation Accumulation in a Selfing Population: Consequences of Different Mutation Rates between Selfers and Outcrossers |
title_short | Mutation Accumulation in a Selfing Population: Consequences of Different Mutation Rates between Selfers and Outcrossers |
title_sort | mutation accumulation in a selfing population: consequences of different mutation rates between selfers and outcrossers |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308984/ https://www.ncbi.nlm.nih.gov/pubmed/22448251 http://dx.doi.org/10.1371/journal.pone.0033541 |
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