Cargando…

Cannabinoid Receptor 2-Mediated Attenuation of CXCR4-Tropic HIV Infection in Primary CD4+ T Cells

Agents that activate cannabinoid receptor pathways have been tested as treatments for cachexia, nausea or neuropathic pain in HIV-1/AIDS patients. The cannabinoid receptors (CB(1)R and CB(2)R) and the HIV-1 co-receptors, CCR5 and CXCR4, all signal via Gαi-coupled pathways. We hypothesized that drugs...

Descripción completa

Detalles Bibliográficos
Autores principales:	Costantino, Cristina Maria, Gupta, Achla, Yewdall, Alice W., Dale, Benjamin M., Devi, Lakshmi A., Chen, Benjamin K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309010/ https://www.ncbi.nlm.nih.gov/pubmed/22448282 http://dx.doi.org/10.1371/journal.pone.0033961

Ejemplares similares

Spermine and spermidine bind CXCR4 and inhibit CXCR4- but not CCR5-tropic HIV-1 infection
por: Harms, Mirja, et al.
Publicado: (2023)

Dimerization with Cannabinoid Receptors Allosterically Modulates Delta Opioid Receptor Activity during Neuropathic Pain
por: Bushlin, Ittai, et al.
Publicado: (2012)

CD4 is expressed on a heterogeneous subset of hematopoietic progenitors, which persistently harbor CXCR4 and CCR5-tropic HIV proviral genomes in vivo
por: Sebastian, Nadia T., et al.
Publicado: (2017)

Inhibition of T-tropic HIV Strains by Selective Antagonization of the Chemokine Receptor CXCR4
por: Schols, Dominique, et al.
Publicado: (1997)

Differential control of CXCR4 and CD4 downregulation by HIV-1 Gag
por: Valiathan, Rajeshwari R, et al.
Publicado: (2008)

Growth potentials of CCR5-tropic/CXCR4-tropic HIV-1mt clones in macaque cells
por: Doi, Naoya, et al.
Publicado: (2013)

Receptor Heteromerization Expands the Repertoire of Cannabinoid Signaling in Rodent Neurons
por: Rozenfeld, Raphael, et al.
Publicado: (2012)

Correction: CD4 is expressed on a heterogeneous subset of hematopoietic progenitors, which persistently harbor CXCR4 and CCR5-tropic HIV proviral genomes in vivo
Publicado: (2017)

A Small Molecule CXCR4 Inhibitor that Blocks T Cell Line–tropic HIV-1 Infection
por: Murakami, Tsutomu, et al.
Publicado: (1997)

CXCR4- and CCR5-Tropic HIV-1 Clones Are Both Tractable to Grow in Rhesus Macaques
por: Doi, Naoya, et al.
Publicado: (2018)

Host cell glycosylation selects for infection with CCR5- versus CXCR4-tropic HIV-1
por: Itell, Hannah L., et al.
Publicado: (2023)

Engineering HIV-Resistant Human CD4+ T Cells with CXCR4-Specific Zinc-Finger Nucleases
por: Wilen, Craig B., et al.
Publicado: (2011)

Limited HIV-2 reservoirs in central-memory CD4 T-cells associated to CXCR6 co-receptor expression in attenuated HIV-2 infection
por: Samri, Assia, et al.
Publicado: (2019)

Emergence of CXCR4-tropic HIV-1 variants followed by rapid disease progression in hemophiliac slow progressors
por: Hayashida, Tsunefusa, et al.
Publicado: (2017)

Unique profile of predominant CCR5-tropic in CRF07_BC HIV-1 infections and discovery of an unusual CXCR4-tropic strain
por: Hu, Xiaoyan, et al.
Publicado: (2022)

Mapping the Lineage Relationship between CXCR5(+) and CXCR5(−) CD4(+) T Cells in HIV-Infected Human Lymph Nodes
por: Del Alcazar, Daniel, et al.
Publicado: (2019)

T cell-tropic HIV efficiently infects alveolar macrophages through contact with infected CD4+ T cells
por: Schiff, Abigail E., et al.
Publicado: (2021)

CXCR4 Antagonism Attenuates the Development of Diabetic Cardiac Fibrosis
por: Chu, Po-Yin, et al.
Publicado: (2015)

Targeted infection of HIV-1 Env expressing cells by HIV(CD4/CXCR4) vectors reveals a potential new rationale for HIV-1 mediated down-modulation of CD4
por: Ye, Zhiping, et al.
Publicado: (2005)

Distinct Roles for CXCR6(+) and CXCR6(−) CD4(+) T Cells in the Pathogenesis of Chronic Colitis
por: Mandai, Yasushi, et al.
Publicado: (2013)

Identification of an unique CXCR4 epitope whose ligation inhibits infection by both CXCR4 and CCR5 tropic human immunodeficiency type-I viruses
por: Adachi, Tetsuya, et al.
Publicado: (2011)

V3 Loop Sequence Space Analysis Suggests Different Evolutionary Patterns of CCR5- and CXCR4-Tropic HIV
por: Bozek, Katarzyna, et al.
Publicado: (2009)

Establishment of a novel CCR5 and CXCR4 expressing CD4(+ )cell line which is highly sensitive to HIV and suitable for high-throughput evaluation of CCR5 and CXCR4 antagonists
por: Princen, Katrien, et al.
Publicado: (2004)

Overexpression of macrophage migration inhibitory factor and functionally-related genes, D-DT, CD74, CD44, CXCR2 and CXCR4, in glioblastoma
por: Presti, Mario, et al.
Publicado: (2018)

Thermal Stability of the Human Immunodeficiency Virus Type 1 (HIV-1) Receptors, CD4 and CXCR4, Reconstituted in Proteoliposomes
por: Zhukovsky, Mikhail A., et al.
Publicado: (2010)

Crosstalk between Chemokine Receptor CXCR4 and Cannabinoid Receptor CB(2) in Modulating Breast Cancer Growth and Invasion
por: Nasser, Mohd W., et al.
Publicado: (2011)

Predicted HIV-1 coreceptor usage among Kenya patients shows a high tendency for subtype d to be cxcr4 tropic
por: Wambui, Veronica, et al.
Publicado: (2012)

Antibodies to probe endogenous G protein-coupled receptor heteromer expression, regulation, and function
por: Gomes, Ivone, et al.
Publicado: (2014)

CD271+, CXCR7+, CXCR4+, and CD133+ Stem/Progenitor Cells and Clinical Characteristics of Acute Ischemic Stroke Patients
por: Gójska-Grymajło, Anna, et al.
Publicado: (2018)

Detection of HIV-1 Neutralizing Antibodies in a Human CD4(+)/CXCR4(+)/CCR5(+) T-Lymphoblastoid Cell Assay System
por: McLinden, Robert J., et al.
Publicado: (2013)

Down-regulation of cell surface CXCR4 by HIV-1
por: Choi, Bongkun, et al.
Publicado: (2008)

Attenuation of osteoarthritis via blockade of the SDF-1/CXCR4 signaling pathway
por: Wei, Fangyuan, et al.
Publicado: (2012)

CXCR4 attenuates cardiomyocytes mitochondrial dysfunction to resist ischaemia-reperfusion injury
por: Cai, Wen-Feng, et al.
Publicado: (2015)

Increased susceptibility of CD4+ T cells from elderly individuals to HIV-1 infection and apoptosis is associated with reduced CD4 and enhanced CXCR4 and FAS surface expression levels
por: Heigele, Anke, et al.
Publicado: (2015)

Genome editing of the HIV co-receptors CCR5 and CXCR4 by CRISPR-Cas9 protects CD4(+) T cells from HIV-1 infection
por: Liu, Zhepeng, et al.
Publicado: (2017)

Natural Scrub Typhus Antibody Suppresses HIV CXCR4(X4) Viruses
por: Watt, George, et al.
Publicado: (2013)

CXCR4 Tropic HIV-1 gp120 Inhibition of SDF-1α-Induced Chemotaxis Requires Lck and is Associated with Cofilin Phosphorylation
por: Trushin, Sergey A, et al.
Publicado: (2010)

Transmission of highly virulent CXCR4 tropic HIV-1 through the mucosal route in an individual with a wild-type CCR5 genotype
por: Song, Hongshuo, et al.
Publicado: (2023)

Type 1 diabetes patients increase CXCR4(+) and CXCR7(+) haematopoietic and endothelial progenitor cells with exercise, but the response is attenuated
por: Taylor, Guy S., et al.
Publicado: (2021)

CXCR4 involvement in neurodegenerative diseases
por: Bonham, Luke W., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_5b08262a3g5sg90595d4bft58o