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Overactivation of Notch1 Signaling Induces Ectopic Hair Cells in the Mouse Inner Ear in an Age-Dependent Manner

BACKGROUND: During mouse inner ear development, Notch1 signaling first specifies sensory progenitors, and subsequently controls progenitors to further differentiate into either hair cells (HCs) or supporting cells (SCs). Overactivation of NICD (Notch1 intracellular domain) at early embryonic stages...

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Detalles Bibliográficos
Autores principales:	Liu, Zhiyong, Owen, Thomas, Fang, Jie, Zuo, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309011/ https://www.ncbi.nlm.nih.gov/pubmed/22448289 http://dx.doi.org/10.1371/journal.pone.0034123

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