Cefepime Neurotoxicity in Patients with Renal Insufficiency

Cefepime is a fourth-generation cephalosporin that is active against both gram-positive and gram-negative organisms. It is administered parenterally for the treatment of severe infections. Approximately 85% of the drug is excreted unchanged by the kidneys. Neurotoxicity in patients with renal failur...

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Detalles Bibliográficos
Autores principales: Kim, Seon-Yu, Lee, In-Sik, Park, Seung Lee, Lee, Jongmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Academy of Rehabilitation Medicine 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309312/
https://www.ncbi.nlm.nih.gov/pubmed/22506251
http://dx.doi.org/10.5535/arm.2012.36.1.159
Descripción
Sumario:Cefepime is a fourth-generation cephalosporin that is active against both gram-positive and gram-negative organisms. It is administered parenterally for the treatment of severe infections. Approximately 85% of the drug is excreted unchanged by the kidneys. Neurotoxicity in patients with renal failure who are treated with cefepime has been reported sporadically. We report on two senile patients with renal impairment who developed neurotoxicity including lethal outcome after treatment with cefepime.

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