Clinical effectiveness of unilateral deep brain stimulation in Tourette syndrome

Dysfunctional basal ganglia loops are thought to underlie the clinical picture of Tourette syndrome (TS). By altering dopaminergic activity in the affected neural structures, bilateral deep brain stimulation is assumed to have a modulatory effect on dopamine transmission resulting in an amelioration...

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Autores principales: Kuhn, J, Bartsch, C, Lenartz, D, Huys, D, Daumann, J, Woopen, C, Hunsche, S, Maarouf, M, Klosterkötter, J, Sturm, V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309474/
https://www.ncbi.nlm.nih.gov/pubmed/22833207
http://dx.doi.org/10.1038/tp.2011.51
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author Kuhn, J
Bartsch, C
Lenartz, D
Huys, D
Daumann, J
Woopen, C
Hunsche, S
Maarouf, M
Klosterkötter, J
Sturm, V
author_facet Kuhn, J
Bartsch, C
Lenartz, D
Huys, D
Daumann, J
Woopen, C
Hunsche, S
Maarouf, M
Klosterkötter, J
Sturm, V
author_sort Kuhn, J
collection PubMed
description Dysfunctional basal ganglia loops are thought to underlie the clinical picture of Tourette syndrome (TS). By altering dopaminergic activity in the affected neural structures, bilateral deep brain stimulation is assumed to have a modulatory effect on dopamine transmission resulting in an amelioration of tics. While the majority of published case reports deals with the application of bilateral stimulation, the present study aims at informing about the high effectiveness of unilateral stimulation of pallidal and nigral thalamic territories in TS. Potential implications and gains of the unilateral approach are discussed.
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spelling pubmed-33094742012-04-03 Clinical effectiveness of unilateral deep brain stimulation in Tourette syndrome Kuhn, J Bartsch, C Lenartz, D Huys, D Daumann, J Woopen, C Hunsche, S Maarouf, M Klosterkötter, J Sturm, V Transl Psychiatry Original Article Dysfunctional basal ganglia loops are thought to underlie the clinical picture of Tourette syndrome (TS). By altering dopaminergic activity in the affected neural structures, bilateral deep brain stimulation is assumed to have a modulatory effect on dopamine transmission resulting in an amelioration of tics. While the majority of published case reports deals with the application of bilateral stimulation, the present study aims at informing about the high effectiveness of unilateral stimulation of pallidal and nigral thalamic territories in TS. Potential implications and gains of the unilateral approach are discussed. Nature Publishing Group 2011-11 2011-11-15 /pmc/articles/PMC3309474/ /pubmed/22833207 http://dx.doi.org/10.1038/tp.2011.51 Text en Copyright © 2011 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Original Article
Kuhn, J
Bartsch, C
Lenartz, D
Huys, D
Daumann, J
Woopen, C
Hunsche, S
Maarouf, M
Klosterkötter, J
Sturm, V
Clinical effectiveness of unilateral deep brain stimulation in Tourette syndrome
title Clinical effectiveness of unilateral deep brain stimulation in Tourette syndrome
title_full Clinical effectiveness of unilateral deep brain stimulation in Tourette syndrome
title_fullStr Clinical effectiveness of unilateral deep brain stimulation in Tourette syndrome
title_full_unstemmed Clinical effectiveness of unilateral deep brain stimulation in Tourette syndrome
title_short Clinical effectiveness of unilateral deep brain stimulation in Tourette syndrome
title_sort clinical effectiveness of unilateral deep brain stimulation in tourette syndrome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309474/
https://www.ncbi.nlm.nih.gov/pubmed/22833207
http://dx.doi.org/10.1038/tp.2011.51
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