Repeat variation in the human PER2 gene as a new genetic marker associated with cocaine addiction and brain dopamine D2 receptor availability

Low dopamine D2 receptor (D2R) levels in the striatum are consistently reported in cocaine abusers; inter-individual variations in the degree of the decrease suggest a modulating effect of genetic makeup on vulnerability to addiction. The PER2 (Period 2) gene belongs to the clock genes family of cir...

Descripción completa

Detalles Bibliográficos
Autores principales: Shumay, E, Fowler, J S, Wang, G-J, Logan, J, Alia-Klein, N, Goldstein, R Z, Maloney, T, Wong, C, Volkow, N D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309530/
https://www.ncbi.nlm.nih.gov/pubmed/22832851
http://dx.doi.org/10.1038/tp.2012.11

Ejemplares similares

Ejemplares similares