Carbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsy

We find that a common mutation that increases angiotensin I-converting enzyme activity occurs with higher frequency in male patients suffering from refractory temporal lobe epilepsy. However, in their brains, the activity of the enzyme is downregulated. As an explanation, we surprisingly find that c...

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Detalles Bibliográficos
Autores principales: Almeida, S S, Naffah-Mazzacoratti, M G, Guimarães, P B, Wasinski, F, Pereira, F E G, Canzian, M, Centeno, R S, Carrete, H, Yacubian, E M, Carmona, A K, Vieira, R F F, Nakaie, C R, Sabatini, R A, Perosa, S R, Bacurau, R F P, Gouveia, T L F, Gallo, G, Würtele, M, Cavalheiro, E A, Silva, J A, Pesquero, J B, Araujo, R C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309532/
https://www.ncbi.nlm.nih.gov/pubmed/22832858
http://dx.doi.org/10.1038/tp.2012.21

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