Multiple Tyrosine Residues Contribute to GABA Binding in the GABA(C) Receptor Binding Pocket

[Image: see text] The ligand binding site of Cys-loop receptors is dominated by aromatic amino acids. In GABA(C) receptors, these are predominantly tyrosine residues, with a number of other aromatic residues located in or close to the binding pocket. Here we examine the roles of these residues using...

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Detalles Bibliográficos
Autores principales: Lummis, Sarah C. R., Harrison, Neil J., Wang, Jinti, Ashby, Jamie A., Millen, Katherine S., Beene, Darren L., Dougherty, Dennis A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309607/
https://www.ncbi.nlm.nih.gov/pubmed/22448304
http://dx.doi.org/10.1021/cn200103n

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