Drug Susceptibility of Mycobacterium tuberculosis Beijing Genotype and Association with MDR TB

To determine differences in the ability of Mycobacterium tuberculosis strains to withstand antituberculosis drug treatment, we compared the activity of antituberculosis drugs against susceptible Beijing and East-African/Indian genotype M. tuberculosis strains. Beijing genotype strains showed high ra...

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Detalles Bibliográficos
Autores principales: de Steenwinkel, Jurriaan E.M., ten Kate, Marian T., de Knegt, Gerjo J., Kremer, Kristin, Aarnoutse, Rob E., Boeree, Martin J., Verbrugh, Henri A., van Soolingen, Dick, Bakker-Woudenberg, Irma A.J.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2012
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309663/
https://www.ncbi.nlm.nih.gov/pubmed/22469099
http://dx.doi.org/10.3201/eid1804.110912
Descripción
Sumario:To determine differences in the ability of Mycobacterium tuberculosis strains to withstand antituberculosis drug treatment, we compared the activity of antituberculosis drugs against susceptible Beijing and East-African/Indian genotype M. tuberculosis strains. Beijing genotype strains showed high rates of mutation within a wide range of drug concentrations, possibly explaining this genotype’s association with multidrug-resistant tuberculosis.

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