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Flexible antibodies with nonprotein hinges

There is a significant need for antibodies that can bind targets with greater affinity. Here we describe a novel strategy employing chemical semisynthesis to produce symmetroadhesins: antibody-like molecules having nonprotein hinge regions that are more flexible and extendible and are capable of two...

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Detalles Bibliográficos
Autores principales:	CAPON, Daniel J., KANEKO, Naoki, YOSHIMORI, Takayuki, SHIMADA, Takashi, WURM, Florian M., HWANG, Peter K., TONG, Xiaohe, ADAMS, Staci A., SIMMONS, Graham, SATO, Taka-Aki, TANAKA, Koichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Japan Academy 2011
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309923/ https://www.ncbi.nlm.nih.gov/pubmed/22075761 http://dx.doi.org/10.2183/pjab.87.603

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