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Olfactory aversive conditioning alters olfactory bulb mitral/tufted cell glomerular odor responses

The anatomical organization of receptor neuron input into the olfactory bulb (OB) allows odor information to be transformed into an odorant-specific spatial map of mitral/tufted (M/T) cell glomerular activity at the upper level of the OB. In other sensory systems, neuronal representations of stimuli...

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Autor principal: Fletcher, Max L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309973/
https://www.ncbi.nlm.nih.gov/pubmed/22461771
http://dx.doi.org/10.3389/fnsys.2012.00016
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author Fletcher, Max L.
author_facet Fletcher, Max L.
author_sort Fletcher, Max L.
collection PubMed
description The anatomical organization of receptor neuron input into the olfactory bulb (OB) allows odor information to be transformed into an odorant-specific spatial map of mitral/tufted (M/T) cell glomerular activity at the upper level of the OB. In other sensory systems, neuronal representations of stimuli can be reorganized or enhanced following learning. While the mammalian OB has been shown to undergo experience-dependent plasticity at the glomerular level, it is still unclear if similar representational change occurs within (M/T) cell glomerular odor representations following learning. To address this, odorant-evoked glomerular activity patterns were imaged in mice expressing a GFP-based calcium indicator (GCaMP2) in OB (M/T) cells. Glomerular odor responses were imaged before and after olfactory associative conditioning to aversive foot shock. Following conditioning, we found no overall reorganization of the glomerular representation. Training, however, did significantly alter the amplitudes of individual glomeruli within the representation in mice in which the odor was presented together with foot shock. Further, the specific pairing of foot shock with odor presentations lead to increased responses primarily in initially weakly activated glomeruli. Overall, these results suggest that associative conditioning can enhance the initial representation of odors within the OB by enhancing responses to the learned odor in some glomeruli.
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spelling pubmed-33099732012-03-29 Olfactory aversive conditioning alters olfactory bulb mitral/tufted cell glomerular odor responses Fletcher, Max L. Front Syst Neurosci Neuroscience The anatomical organization of receptor neuron input into the olfactory bulb (OB) allows odor information to be transformed into an odorant-specific spatial map of mitral/tufted (M/T) cell glomerular activity at the upper level of the OB. In other sensory systems, neuronal representations of stimuli can be reorganized or enhanced following learning. While the mammalian OB has been shown to undergo experience-dependent plasticity at the glomerular level, it is still unclear if similar representational change occurs within (M/T) cell glomerular odor representations following learning. To address this, odorant-evoked glomerular activity patterns were imaged in mice expressing a GFP-based calcium indicator (GCaMP2) in OB (M/T) cells. Glomerular odor responses were imaged before and after olfactory associative conditioning to aversive foot shock. Following conditioning, we found no overall reorganization of the glomerular representation. Training, however, did significantly alter the amplitudes of individual glomeruli within the representation in mice in which the odor was presented together with foot shock. Further, the specific pairing of foot shock with odor presentations lead to increased responses primarily in initially weakly activated glomeruli. Overall, these results suggest that associative conditioning can enhance the initial representation of odors within the OB by enhancing responses to the learned odor in some glomeruli. Frontiers Media S.A. 2012-03-22 /pmc/articles/PMC3309973/ /pubmed/22461771 http://dx.doi.org/10.3389/fnsys.2012.00016 Text en Copyright © 2012 Fletcher. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Neuroscience
Fletcher, Max L.
Olfactory aversive conditioning alters olfactory bulb mitral/tufted cell glomerular odor responses
title Olfactory aversive conditioning alters olfactory bulb mitral/tufted cell glomerular odor responses
title_full Olfactory aversive conditioning alters olfactory bulb mitral/tufted cell glomerular odor responses
title_fullStr Olfactory aversive conditioning alters olfactory bulb mitral/tufted cell glomerular odor responses
title_full_unstemmed Olfactory aversive conditioning alters olfactory bulb mitral/tufted cell glomerular odor responses
title_short Olfactory aversive conditioning alters olfactory bulb mitral/tufted cell glomerular odor responses
title_sort olfactory aversive conditioning alters olfactory bulb mitral/tufted cell glomerular odor responses
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309973/
https://www.ncbi.nlm.nih.gov/pubmed/22461771
http://dx.doi.org/10.3389/fnsys.2012.00016
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