E-Cadherin Destabilization Accounts for the Pathogenicity of Missense Mutations in Hereditary Diffuse Gastric Cancer

E-cadherin is critical for the maintenance of tissue architecture due to its role in cell-cell adhesion. E-cadherin mutations are the genetic cause of Hereditary Diffuse Gastric Cancer (HDGC) and missense mutations represent a clinical burden, due to the uncertainty of their pathogenic role. In vitr...

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Detalles Bibliográficos
Autores principales: Simões-Correia, Joana, Figueiredo, Joana, Lopes, Rui, Stricher, François, Oliveira, Carla, Serrano, Luis, Seruca, Raquel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309996/
https://www.ncbi.nlm.nih.gov/pubmed/22470475
http://dx.doi.org/10.1371/journal.pone.0033783

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