High Prevalence of Multidrug-Resistant Tuberculosis, Swaziland, 2009–2010

In Africa, although emergence of multidrug-resistant (MDR) tuberculosis (TB) represents a serious threat in countries severely affected by the HIV epidemic, most countries lack drug-resistant TB data. This finding was particularly true in the Kingdom of Swaziland, which has the world’s highest HIV a...

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Detalles Bibliográficos
Autores principales: Sanchez-Padilla, Elisabeth, Dlamini, Themba, Ascorra, Alexandra, Rüsch-Gerdes, Sabine, Tefera, Zerihun Demissie, Calain, Philippe, de la Tour, Roberto, Jochims, Frauke, Richter, Elvira, Bonnet, Maryline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310109/
https://www.ncbi.nlm.nih.gov/pubmed/22260950
http://dx.doi.org/10.3201/eid1801.110850
Descripción
Sumario:In Africa, although emergence of multidrug-resistant (MDR) tuberculosis (TB) represents a serious threat in countries severely affected by the HIV epidemic, most countries lack drug-resistant TB data. This finding was particularly true in the Kingdom of Swaziland, which has the world’s highest HIV and TB prevalences. Therefore, we conducted a national survey in 2009–2010 to measure prevalence of drug-resistant TB. Of 988 patients screened, 420 new case-patients and 420 previously treated case-patients met the study criteria. Among culture-positive patients, 15.3% new case-patients and 49.5% previously treated case-patients harbored drug-resistant strains. MDR TB prevalence was 7.7% and 33.8% among new case-patients and previously treated case-patients, respectively. HIV infection and past TB treatment were independently associated with MDR TB. The findings assert the need for wide-scale intervention in resource-limited contexts such as Swaziland, where diagnostic and treatment facilities and health personnel are lacking.

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