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Invasive Meningococcal Capsular Group Y Disease, England and Wales, 2007–2009

Enhanced national surveillance for invasive meningococcal disease in England and Wales identified an increase in laboratory-confirmed capsular group Y (MenY) disease from 34 cases in 2007 to 44 in 2008 and 65 in 2009. For cases diagnosed in 2009, patient median age at disease onset was 60 years; 39%...

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Autores principales: Ladhani, Shamez N., Lucidarme, Jay, Newbold, Lynne S., Gray, Stephen J., Carr, Anthony D., Findlow, Jamie, Ramsay, Mary E., Kaczmarski, Edward B., Borrow, Raymond
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310110/
https://www.ncbi.nlm.nih.gov/pubmed/22261040
http://dx.doi.org/10.3201/eid1801.110901
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author Ladhani, Shamez N.
Lucidarme, Jay
Newbold, Lynne S.
Gray, Stephen J.
Carr, Anthony D.
Findlow, Jamie
Ramsay, Mary E.
Kaczmarski, Edward B.
Borrow, Raymond
author_facet Ladhani, Shamez N.
Lucidarme, Jay
Newbold, Lynne S.
Gray, Stephen J.
Carr, Anthony D.
Findlow, Jamie
Ramsay, Mary E.
Kaczmarski, Edward B.
Borrow, Raymond
author_sort Ladhani, Shamez N.
collection PubMed
description Enhanced national surveillance for invasive meningococcal disease in England and Wales identified an increase in laboratory-confirmed capsular group Y (MenY) disease from 34 cases in 2007 to 44 in 2008 and 65 in 2009. For cases diagnosed in 2009, patient median age at disease onset was 60 years; 39% of patients had underlying medical conditions, and 19% died. MenY isolates causing invasive disease during 2007–2009 belonged mainly to 1 of 4 clonal complexes (cc), cc23 (56% of isolates), cc174 (21%), cc167 (11%), and cc22 (8%). The 2009 increase resulted primarily from sequence type 1655 (cc23) (22 cases in 2009, compared with 4 cases each in 2007 and 2008). cc23 was associated with lpxL1 mutations and meningitis in younger age groups (<25 years); cc174 was associated with nonmeningitis, particularly pneumonia, in older age groups (>65 years). The increase in MenY disease requires careful epidemiologic and molecular monitoring.
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spelling pubmed-33101102012-04-10 Invasive Meningococcal Capsular Group Y Disease, England and Wales, 2007–2009 Ladhani, Shamez N. Lucidarme, Jay Newbold, Lynne S. Gray, Stephen J. Carr, Anthony D. Findlow, Jamie Ramsay, Mary E. Kaczmarski, Edward B. Borrow, Raymond Emerg Infect Dis Research Enhanced national surveillance for invasive meningococcal disease in England and Wales identified an increase in laboratory-confirmed capsular group Y (MenY) disease from 34 cases in 2007 to 44 in 2008 and 65 in 2009. For cases diagnosed in 2009, patient median age at disease onset was 60 years; 39% of patients had underlying medical conditions, and 19% died. MenY isolates causing invasive disease during 2007–2009 belonged mainly to 1 of 4 clonal complexes (cc), cc23 (56% of isolates), cc174 (21%), cc167 (11%), and cc22 (8%). The 2009 increase resulted primarily from sequence type 1655 (cc23) (22 cases in 2009, compared with 4 cases each in 2007 and 2008). cc23 was associated with lpxL1 mutations and meningitis in younger age groups (<25 years); cc174 was associated with nonmeningitis, particularly pneumonia, in older age groups (>65 years). The increase in MenY disease requires careful epidemiologic and molecular monitoring. Centers for Disease Control and Prevention 2012-01 /pmc/articles/PMC3310110/ /pubmed/22261040 http://dx.doi.org/10.3201/eid1801.110901 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Ladhani, Shamez N.
Lucidarme, Jay
Newbold, Lynne S.
Gray, Stephen J.
Carr, Anthony D.
Findlow, Jamie
Ramsay, Mary E.
Kaczmarski, Edward B.
Borrow, Raymond
Invasive Meningococcal Capsular Group Y Disease, England and Wales, 2007–2009
title Invasive Meningococcal Capsular Group Y Disease, England and Wales, 2007–2009
title_full Invasive Meningococcal Capsular Group Y Disease, England and Wales, 2007–2009
title_fullStr Invasive Meningococcal Capsular Group Y Disease, England and Wales, 2007–2009
title_full_unstemmed Invasive Meningococcal Capsular Group Y Disease, England and Wales, 2007–2009
title_short Invasive Meningococcal Capsular Group Y Disease, England and Wales, 2007–2009
title_sort invasive meningococcal capsular group y disease, england and wales, 2007–2009
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310110/
https://www.ncbi.nlm.nih.gov/pubmed/22261040
http://dx.doi.org/10.3201/eid1801.110901
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