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Invasive Meningococcal Capsular Group Y Disease, England and Wales, 2007–2009
Enhanced national surveillance for invasive meningococcal disease in England and Wales identified an increase in laboratory-confirmed capsular group Y (MenY) disease from 34 cases in 2007 to 44 in 2008 and 65 in 2009. For cases diagnosed in 2009, patient median age at disease onset was 60 years; 39%...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310110/ https://www.ncbi.nlm.nih.gov/pubmed/22261040 http://dx.doi.org/10.3201/eid1801.110901 |
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author | Ladhani, Shamez N. Lucidarme, Jay Newbold, Lynne S. Gray, Stephen J. Carr, Anthony D. Findlow, Jamie Ramsay, Mary E. Kaczmarski, Edward B. Borrow, Raymond |
author_facet | Ladhani, Shamez N. Lucidarme, Jay Newbold, Lynne S. Gray, Stephen J. Carr, Anthony D. Findlow, Jamie Ramsay, Mary E. Kaczmarski, Edward B. Borrow, Raymond |
author_sort | Ladhani, Shamez N. |
collection | PubMed |
description | Enhanced national surveillance for invasive meningococcal disease in England and Wales identified an increase in laboratory-confirmed capsular group Y (MenY) disease from 34 cases in 2007 to 44 in 2008 and 65 in 2009. For cases diagnosed in 2009, patient median age at disease onset was 60 years; 39% of patients had underlying medical conditions, and 19% died. MenY isolates causing invasive disease during 2007–2009 belonged mainly to 1 of 4 clonal complexes (cc), cc23 (56% of isolates), cc174 (21%), cc167 (11%), and cc22 (8%). The 2009 increase resulted primarily from sequence type 1655 (cc23) (22 cases in 2009, compared with 4 cases each in 2007 and 2008). cc23 was associated with lpxL1 mutations and meningitis in younger age groups (<25 years); cc174 was associated with nonmeningitis, particularly pneumonia, in older age groups (>65 years). The increase in MenY disease requires careful epidemiologic and molecular monitoring. |
format | Online Article Text |
id | pubmed-3310110 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-33101102012-04-10 Invasive Meningococcal Capsular Group Y Disease, England and Wales, 2007–2009 Ladhani, Shamez N. Lucidarme, Jay Newbold, Lynne S. Gray, Stephen J. Carr, Anthony D. Findlow, Jamie Ramsay, Mary E. Kaczmarski, Edward B. Borrow, Raymond Emerg Infect Dis Research Enhanced national surveillance for invasive meningococcal disease in England and Wales identified an increase in laboratory-confirmed capsular group Y (MenY) disease from 34 cases in 2007 to 44 in 2008 and 65 in 2009. For cases diagnosed in 2009, patient median age at disease onset was 60 years; 39% of patients had underlying medical conditions, and 19% died. MenY isolates causing invasive disease during 2007–2009 belonged mainly to 1 of 4 clonal complexes (cc), cc23 (56% of isolates), cc174 (21%), cc167 (11%), and cc22 (8%). The 2009 increase resulted primarily from sequence type 1655 (cc23) (22 cases in 2009, compared with 4 cases each in 2007 and 2008). cc23 was associated with lpxL1 mutations and meningitis in younger age groups (<25 years); cc174 was associated with nonmeningitis, particularly pneumonia, in older age groups (>65 years). The increase in MenY disease requires careful epidemiologic and molecular monitoring. Centers for Disease Control and Prevention 2012-01 /pmc/articles/PMC3310110/ /pubmed/22261040 http://dx.doi.org/10.3201/eid1801.110901 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Ladhani, Shamez N. Lucidarme, Jay Newbold, Lynne S. Gray, Stephen J. Carr, Anthony D. Findlow, Jamie Ramsay, Mary E. Kaczmarski, Edward B. Borrow, Raymond Invasive Meningococcal Capsular Group Y Disease, England and Wales, 2007–2009 |
title | Invasive Meningococcal Capsular Group Y Disease, England and Wales, 2007–2009 |
title_full | Invasive Meningococcal Capsular Group Y Disease, England and Wales, 2007–2009 |
title_fullStr | Invasive Meningococcal Capsular Group Y Disease, England and Wales, 2007–2009 |
title_full_unstemmed | Invasive Meningococcal Capsular Group Y Disease, England and Wales, 2007–2009 |
title_short | Invasive Meningococcal Capsular Group Y Disease, England and Wales, 2007–2009 |
title_sort | invasive meningococcal capsular group y disease, england and wales, 2007–2009 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310110/ https://www.ncbi.nlm.nih.gov/pubmed/22261040 http://dx.doi.org/10.3201/eid1801.110901 |
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