Mutations I117V and I117M and Oseltamivir Sensitivity of Pandemic (H1N1) 2009 Viruses

Analysis of mutations I117V and I117M in the neuraminidase of influenza A pandemic (H1N1) 2009 viruses showed that I117V confers a mild reduction in oseltamivir sensitivity and has a synergistic effect of further increasing resistance when combined with H275Y. Contrary to recent reports, the I117M m...

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Autores principales: Hurt, Aeron C., Leang, Sook Kwan, Speers, David J., Barr, Ian G., Maurer-Stroh, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2012
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310118/
https://www.ncbi.nlm.nih.gov/pubmed/22260817
http://dx.doi.org/10.3201/eid1801.111079
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author Hurt, Aeron C.
Leang, Sook Kwan
Speers, David J.
Barr, Ian G.
Maurer-Stroh, Sebastian
author_facet Hurt, Aeron C.
Leang, Sook Kwan
Speers, David J.
Barr, Ian G.
Maurer-Stroh, Sebastian
author_sort Hurt, Aeron C.
collection PubMed
description Analysis of mutations I117V and I117M in the neuraminidase of influenza A pandemic (H1N1) 2009 viruses showed that I117V confers a mild reduction in oseltamivir sensitivity and has a synergistic effect of further increasing resistance when combined with H275Y. Contrary to recent reports, the I117M mutation does not alter oseltamivir sensitivity.
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spelling pubmed-33101182012-04-10 Mutations I117V and I117M and Oseltamivir Sensitivity of Pandemic (H1N1) 2009 Viruses Hurt, Aeron C. Leang, Sook Kwan Speers, David J. Barr, Ian G. Maurer-Stroh, Sebastian Emerg Infect Dis Dispatch Analysis of mutations I117V and I117M in the neuraminidase of influenza A pandemic (H1N1) 2009 viruses showed that I117V confers a mild reduction in oseltamivir sensitivity and has a synergistic effect of further increasing resistance when combined with H275Y. Contrary to recent reports, the I117M mutation does not alter oseltamivir sensitivity. Centers for Disease Control and Prevention 2012-01 /pmc/articles/PMC3310118/ /pubmed/22260817 http://dx.doi.org/10.3201/eid1801.111079 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Hurt, Aeron C.
Leang, Sook Kwan
Speers, David J.
Barr, Ian G.
Maurer-Stroh, Sebastian
Mutations I117V and I117M and Oseltamivir Sensitivity of Pandemic (H1N1) 2009 Viruses
title Mutations I117V and I117M and Oseltamivir Sensitivity of Pandemic (H1N1) 2009 Viruses
title_full Mutations I117V and I117M and Oseltamivir Sensitivity of Pandemic (H1N1) 2009 Viruses
title_fullStr Mutations I117V and I117M and Oseltamivir Sensitivity of Pandemic (H1N1) 2009 Viruses
title_full_unstemmed Mutations I117V and I117M and Oseltamivir Sensitivity of Pandemic (H1N1) 2009 Viruses
title_short Mutations I117V and I117M and Oseltamivir Sensitivity of Pandemic (H1N1) 2009 Viruses
title_sort mutations i117v and i117m and oseltamivir sensitivity of pandemic (h1n1) 2009 viruses
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310118/
https://www.ncbi.nlm.nih.gov/pubmed/22260817
http://dx.doi.org/10.3201/eid1801.111079
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