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Polymorphisms in HSD17B1: Early Onset and Increased Risk of Alzheimer's Disease in Women with Down Syndrome

Background/Aims. Genetic variants that affect estrogen activity may influence the risk of Alzheimer's disease (AD). In women with Down syndrome, we examined the relation of polymorphisms in hydroxysteroid-17beta-dehydrogenase (HSD17B1) to age at onset and risk of AD. HSD17B1 encodes the enzyme...

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Detalles Bibliográficos
Autores principales:	Lee, Joseph H., Gurney, Susan, Pang, Deborah, Temkin, Alexis, Park, Naeun, Janicki, Sarah C., Zigman, Warren B., Silverman, Wayne, Tycko, Benjamin, Schupf, Nicole
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310186/ https://www.ncbi.nlm.nih.gov/pubmed/22474448 http://dx.doi.org/10.1155/2012/361218

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