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Relationship between Concentration Difference of Different Density Lipoproteins and Shear Stress in Atherosclerosis

Previous research has observed concentration polarization in LDL and HDL in the arterial system. However, there is no report that links this concentration polarization to the development of vascular atherosclerosis (AS). Therefore, the purpose of this study is to establish the relationship between c...

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Detalles Bibliográficos
Autores principales: Meng, Wei, Yu, Fengxu, Chen, Huaiqing, Zhang, Jianmin, Zhang, Eryong, Guo, Yingqiang, Shi, Yingkang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310262/
https://www.ncbi.nlm.nih.gov/pubmed/22481972
http://dx.doi.org/10.1155/2012/135256
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author Meng, Wei
Yu, Fengxu
Chen, Huaiqing
Zhang, Jianmin
Zhang, Eryong
Guo, Yingqiang
Shi, Yingkang
author_facet Meng, Wei
Yu, Fengxu
Chen, Huaiqing
Zhang, Jianmin
Zhang, Eryong
Guo, Yingqiang
Shi, Yingkang
author_sort Meng, Wei
collection PubMed
description Previous research has observed concentration polarization in LDL and HDL in the arterial system. However, there is no report that links this concentration polarization to the development of vascular atherosclerosis (AS). Therefore, the purpose of this study is to establish the relationship between concentration difference of LDL and HDL and shear stress using a carotid bifurcation vascular model. PTFE was employed to create the carotid bifurcation model. Endothelial cells were coated on the inner wall of the graft. In a recirculation system, HDL and LDL concentration were measured under two different ICA flow velocities at 5 different locations within our model. We report the following: (1) LDL and HDL concentration difference was observed in both high flow and low flow environments; (2) the degree of LDL and HDL concentration polarization varied depending of high flow and low flow environment; (3) absolute values of concentration difference between LDL and HDL at the inner wall surface decreased with the increase in shear stress when shear stress was more than 1.5 Pa. This variation trend would be more pronounced if shear stress were less than 0.5 Pa. Our study suggests that under the action of shear stress, concentration differences of LDL or HDL create a disturbance in the balance of atherogenic factors and anti-As factors, resulting in the occurrence of AS.
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spelling pubmed-33102622012-04-05 Relationship between Concentration Difference of Different Density Lipoproteins and Shear Stress in Atherosclerosis Meng, Wei Yu, Fengxu Chen, Huaiqing Zhang, Jianmin Zhang, Eryong Guo, Yingqiang Shi, Yingkang Comput Math Methods Med Research Article Previous research has observed concentration polarization in LDL and HDL in the arterial system. However, there is no report that links this concentration polarization to the development of vascular atherosclerosis (AS). Therefore, the purpose of this study is to establish the relationship between concentration difference of LDL and HDL and shear stress using a carotid bifurcation vascular model. PTFE was employed to create the carotid bifurcation model. Endothelial cells were coated on the inner wall of the graft. In a recirculation system, HDL and LDL concentration were measured under two different ICA flow velocities at 5 different locations within our model. We report the following: (1) LDL and HDL concentration difference was observed in both high flow and low flow environments; (2) the degree of LDL and HDL concentration polarization varied depending of high flow and low flow environment; (3) absolute values of concentration difference between LDL and HDL at the inner wall surface decreased with the increase in shear stress when shear stress was more than 1.5 Pa. This variation trend would be more pronounced if shear stress were less than 0.5 Pa. Our study suggests that under the action of shear stress, concentration differences of LDL or HDL create a disturbance in the balance of atherogenic factors and anti-As factors, resulting in the occurrence of AS. Hindawi Publishing Corporation 2012 2012-03-07 /pmc/articles/PMC3310262/ /pubmed/22481972 http://dx.doi.org/10.1155/2012/135256 Text en Copyright © 2012 Wei Meng et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Meng, Wei
Yu, Fengxu
Chen, Huaiqing
Zhang, Jianmin
Zhang, Eryong
Guo, Yingqiang
Shi, Yingkang
Relationship between Concentration Difference of Different Density Lipoproteins and Shear Stress in Atherosclerosis
title Relationship between Concentration Difference of Different Density Lipoproteins and Shear Stress in Atherosclerosis
title_full Relationship between Concentration Difference of Different Density Lipoproteins and Shear Stress in Atherosclerosis
title_fullStr Relationship between Concentration Difference of Different Density Lipoproteins and Shear Stress in Atherosclerosis
title_full_unstemmed Relationship between Concentration Difference of Different Density Lipoproteins and Shear Stress in Atherosclerosis
title_short Relationship between Concentration Difference of Different Density Lipoproteins and Shear Stress in Atherosclerosis
title_sort relationship between concentration difference of different density lipoproteins and shear stress in atherosclerosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310262/
https://www.ncbi.nlm.nih.gov/pubmed/22481972
http://dx.doi.org/10.1155/2012/135256
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