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Post-Aire Maturation of Thymic Medullary Epithelial Cells Involves Selective Expression of Keratinocyte-Specific Autoantigens

The autoimmune regulator (Aire)-directed ectopic expression of tissue-specific antigens (TSAs) by mature medullary thymic epithelial cells (mTECs) has been viewed as an essential mechanism in the induction of central tolerance. Recent data suggest that the survival of mTECs extends beyond the Aire+...

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Detalles Bibliográficos
Autores principales:	Wang, Xiaoping, Laan, Martti, Bichele, Rudolf, Kisand, Kai, Scott, Hamish S., Peterson, Pärt
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Research Foundation 2012
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310317/ https://www.ncbi.nlm.nih.gov/pubmed/22448160 http://dx.doi.org/10.3389/fimmu.2012.00019

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