Role of hydroxypropyl-β-cyclodextrin on freeze-dried and gamma-irradiated PLGA and PLGA–PEG diblock copolymer nanospheres for ophthalmic flurbiprofen delivery

Poly(D,L-lactide-co-glycolide) and poly(D,L-lactide-co-glycolide) with poly(ethylene glycol) nanospheres (NSs) incorporating flurbiprofen (FB) were freeze-dried with several cryoprotective agents and sterilized by γ-irradiation. Only when 5.0% (w/v) hydroxypropyl-β-cyclodextrin (HPβCD) was used, a c...

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Detalles Bibliográficos
Autores principales: Vega, Estefanía, Egea, M Antònia, Calpena, Ana Cristina, Espina, Marta, García, M Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310410/
https://www.ncbi.nlm.nih.gov/pubmed/22457594
http://dx.doi.org/10.2147/IJN.S28481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310410/
https://www.ncbi.nlm.nih.gov/pubmed/22457594
http://dx.doi.org/10.2147/IJN.S28481

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