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Increased brain radioactivity by intranasal (32)P-labeled siRNA dendriplexes within in situ-forming mucoadhesive gels

BACKGROUND: Molecules taken up by olfactory and trigeminal nerve neurons directly access the brain by the nose-to-brain pathway. In situ-forming mucoadhesive gels would increase the residence time of intranasal material, favoring the nose-to-brain delivery. In this first approach, brain radioactivit...

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Detalles Bibliográficos
Autores principales:	Perez, Ana Paula, Mundiña-Weilenmann, Cecilia, Romero, Eder Lilia, Morilla, Maria Jose
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2012
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310412/ https://www.ncbi.nlm.nih.gov/pubmed/22457595 http://dx.doi.org/10.2147/IJN.S28261

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