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Identification and characterization of lipopolysaccharide binding protein (LBP) as an estrogen receptor α specific serum biomarker

Estrogen Receptor a (ERα) and Estrogen Receptor β (ERβ) are steroid nuclear receptors that transduce estrogen signaling to control diverse physiological processes linked to reproduction, bone remodeling, behavior, immune response and endocrine-related diseases. In order to differentiate between ERα...

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Detalles Bibliográficos
Autores principales: Chisamore, Michael J, Hong, Kwok-lam Karen, Cheng, Chun, Alves, Stephen E, Rohrer, Susan P, Wilkinson, Hilary A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Informa Healthcare 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310483/
https://www.ncbi.nlm.nih.gov/pubmed/22299632
http://dx.doi.org/10.3109/1354750X.2012.654406
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author Chisamore, Michael J
Hong, Kwok-lam Karen
Cheng, Chun
Alves, Stephen E
Rohrer, Susan P
Wilkinson, Hilary A
author_facet Chisamore, Michael J
Hong, Kwok-lam Karen
Cheng, Chun
Alves, Stephen E
Rohrer, Susan P
Wilkinson, Hilary A
author_sort Chisamore, Michael J
collection PubMed
description Estrogen Receptor a (ERα) and Estrogen Receptor β (ERβ) are steroid nuclear receptors that transduce estrogen signaling to control diverse physiological processes linked to reproduction, bone remodeling, behavior, immune response and endocrine-related diseases. In order to differentiate between ERα and ERβ mediated effects in vivo, ER subtype selective biomarkers are essential. We utilized ERα knockout (AERKO) and ERβ knockout (BERKO) mouse liver RNA and genome wide profiling to identify novel ERα selective serum biomarker candidates. Results from the gene array experiments were validated using real-time RT-PCR and subsequent ELISA's to demonstrate changes in serum proteins. Here we present data that Lipopolysacharide Binding Protein (LBP) is a novel liver-derived ERα selective biomarker that can be measured in serum.
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spelling pubmed-33104832012-04-03 Identification and characterization of lipopolysaccharide binding protein (LBP) as an estrogen receptor α specific serum biomarker Chisamore, Michael J Hong, Kwok-lam Karen Cheng, Chun Alves, Stephen E Rohrer, Susan P Wilkinson, Hilary A Biomarkers Research Article Estrogen Receptor a (ERα) and Estrogen Receptor β (ERβ) are steroid nuclear receptors that transduce estrogen signaling to control diverse physiological processes linked to reproduction, bone remodeling, behavior, immune response and endocrine-related diseases. In order to differentiate between ERα and ERβ mediated effects in vivo, ER subtype selective biomarkers are essential. We utilized ERα knockout (AERKO) and ERβ knockout (BERKO) mouse liver RNA and genome wide profiling to identify novel ERα selective serum biomarker candidates. Results from the gene array experiments were validated using real-time RT-PCR and subsequent ELISA's to demonstrate changes in serum proteins. Here we present data that Lipopolysacharide Binding Protein (LBP) is a novel liver-derived ERα selective biomarker that can be measured in serum. Informa Healthcare 2012-03 2012-02-03 /pmc/articles/PMC3310483/ /pubmed/22299632 http://dx.doi.org/10.3109/1354750X.2012.654406 Text en © 2012 Informa Healthcare UK, Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open access article distributed under the Supplemental Terms and Conditions for iOpenAccess articles published in Informa Healthcare journals (http://www.informaworld.com/mpp/uploads/iopenaccess_tcs.pdf) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chisamore, Michael J
Hong, Kwok-lam Karen
Cheng, Chun
Alves, Stephen E
Rohrer, Susan P
Wilkinson, Hilary A
Identification and characterization of lipopolysaccharide binding protein (LBP) as an estrogen receptor α specific serum biomarker
title Identification and characterization of lipopolysaccharide binding protein (LBP) as an estrogen receptor α specific serum biomarker
title_full Identification and characterization of lipopolysaccharide binding protein (LBP) as an estrogen receptor α specific serum biomarker
title_fullStr Identification and characterization of lipopolysaccharide binding protein (LBP) as an estrogen receptor α specific serum biomarker
title_full_unstemmed Identification and characterization of lipopolysaccharide binding protein (LBP) as an estrogen receptor α specific serum biomarker
title_short Identification and characterization of lipopolysaccharide binding protein (LBP) as an estrogen receptor α specific serum biomarker
title_sort identification and characterization of lipopolysaccharide binding protein (lbp) as an estrogen receptor α specific serum biomarker
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310483/
https://www.ncbi.nlm.nih.gov/pubmed/22299632
http://dx.doi.org/10.3109/1354750X.2012.654406
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