Persistence of Resistant Staphylococcus epidermidis after Single Course of Clarithromycin

We examined how a common therapy that includes clarithromycin affects normally colonizing Staphylococcus epidermidis. Samples from the nostrils of 5 patients receiving therapy were collected before, immediately after, 1 year after, and 4 years after treatment. From each patient and sample, S. epider...

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Detalles Bibliográficos
Autores principales: Sjölund, Maria, Tano, Eva, Blaser, Martin J., Andersson, Dan I., Engstrand, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2005
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310621/
https://www.ncbi.nlm.nih.gov/pubmed/16229767
http://dx.doi.org/10.3201/eid1109.050124
Descripción
Sumario:We examined how a common therapy that includes clarithromycin affects normally colonizing Staphylococcus epidermidis. Samples from the nostrils of 5 patients receiving therapy were collected before, immediately after, 1 year after, and 4 years after treatment. From each patient and sample, S. epidermidis strains were isolated and analyzed for clarithromycin susceptibility and presence of the erm(C) gene. We show that macrolide-resistant strains of S. epidermidis were selected during therapy and that the same resistant strain may persist for 4 years, in the absence of further antimicrobial treatment.

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