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Persistence of Resistant Staphylococcus epidermidis after Single Course of Clarithromycin

We examined how a common therapy that includes clarithromycin affects normally colonizing Staphylococcus epidermidis. Samples from the nostrils of 5 patients receiving therapy were collected before, immediately after, 1 year after, and 4 years after treatment. From each patient and sample, S. epider...

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Detalles Bibliográficos
Autores principales: Sjölund, Maria, Tano, Eva, Blaser, Martin J., Andersson, Dan I., Engstrand, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310621/
https://www.ncbi.nlm.nih.gov/pubmed/16229767
http://dx.doi.org/10.3201/eid1109.050124
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author Sjölund, Maria
Tano, Eva
Blaser, Martin J.
Andersson, Dan I.
Engstrand, Lars
author_facet Sjölund, Maria
Tano, Eva
Blaser, Martin J.
Andersson, Dan I.
Engstrand, Lars
author_sort Sjölund, Maria
collection PubMed
description We examined how a common therapy that includes clarithromycin affects normally colonizing Staphylococcus epidermidis. Samples from the nostrils of 5 patients receiving therapy were collected before, immediately after, 1 year after, and 4 years after treatment. From each patient and sample, S. epidermidis strains were isolated and analyzed for clarithromycin susceptibility and presence of the erm(C) gene. We show that macrolide-resistant strains of S. epidermidis were selected during therapy and that the same resistant strain may persist for 4 years, in the absence of further antimicrobial treatment.
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spelling pubmed-33106212012-04-06 Persistence of Resistant Staphylococcus epidermidis after Single Course of Clarithromycin Sjölund, Maria Tano, Eva Blaser, Martin J. Andersson, Dan I. Engstrand, Lars Emerg Infect Dis Research We examined how a common therapy that includes clarithromycin affects normally colonizing Staphylococcus epidermidis. Samples from the nostrils of 5 patients receiving therapy were collected before, immediately after, 1 year after, and 4 years after treatment. From each patient and sample, S. epidermidis strains were isolated and analyzed for clarithromycin susceptibility and presence of the erm(C) gene. We show that macrolide-resistant strains of S. epidermidis were selected during therapy and that the same resistant strain may persist for 4 years, in the absence of further antimicrobial treatment. Centers for Disease Control and Prevention 2005-09 /pmc/articles/PMC3310621/ /pubmed/16229767 http://dx.doi.org/10.3201/eid1109.050124 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Sjölund, Maria
Tano, Eva
Blaser, Martin J.
Andersson, Dan I.
Engstrand, Lars
Persistence of Resistant Staphylococcus epidermidis after Single Course of Clarithromycin
title Persistence of Resistant Staphylococcus epidermidis after Single Course of Clarithromycin
title_full Persistence of Resistant Staphylococcus epidermidis after Single Course of Clarithromycin
title_fullStr Persistence of Resistant Staphylococcus epidermidis after Single Course of Clarithromycin
title_full_unstemmed Persistence of Resistant Staphylococcus epidermidis after Single Course of Clarithromycin
title_short Persistence of Resistant Staphylococcus epidermidis after Single Course of Clarithromycin
title_sort persistence of resistant staphylococcus epidermidis after single course of clarithromycin
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310621/
https://www.ncbi.nlm.nih.gov/pubmed/16229767
http://dx.doi.org/10.3201/eid1109.050124
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