Plasmodium knowlesi Malaria in Humans and Macaques, Thailand

Naturally acquired human infections with Plasmodium knowlesi are endemic to Southeast Asia. To determine the prevalence of P. knowlesi malaria in malaria-endemic areas of Thailand, we analyzed genetic characteristics of P. knowlesi circulating among naturally infected macaques and humans. This study...

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Autores principales: Jongwutiwes, Somchai, Buppan, Pattakorn, Kosuvin, Rattiporn, Seethamchai, Sunee, Pattanawong, Urassaya, Sirichaisinthop, Jeeraphat, Putaporntip, Chaturong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310673/
https://www.ncbi.nlm.nih.gov/pubmed/22000348
http://dx.doi.org/10.3201/eid1710.110349
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author Jongwutiwes, Somchai
Buppan, Pattakorn
Kosuvin, Rattiporn
Seethamchai, Sunee
Pattanawong, Urassaya
Sirichaisinthop, Jeeraphat
Putaporntip, Chaturong
author_facet Jongwutiwes, Somchai
Buppan, Pattakorn
Kosuvin, Rattiporn
Seethamchai, Sunee
Pattanawong, Urassaya
Sirichaisinthop, Jeeraphat
Putaporntip, Chaturong
author_sort Jongwutiwes, Somchai
collection PubMed
description Naturally acquired human infections with Plasmodium knowlesi are endemic to Southeast Asia. To determine the prevalence of P. knowlesi malaria in malaria-endemic areas of Thailand, we analyzed genetic characteristics of P. knowlesi circulating among naturally infected macaques and humans. This study in 2008–2009 and retrospective analysis of malaria species in human blood samples obtained in 1996 from 1 of these areas showed that P. knowlesi accounted for 0.67% and 0.48% of human malaria cases, respectively, indicating that this simian parasite is not a newly emergent human pathogen in Thailand. Sequence analysis of the complete merozoite surface protein 1 gene of P. knowlesi from 10 human and 5 macaque blood samples showed considerable genetic diversity among isolates. The sequence from 1 patient was identical with that from a pig-tailed macaque living in the same locality, suggesting cross-transmission of P. knowlesi from naturally infected macaques to humans.
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spelling pubmed-33106732012-06-27 Plasmodium knowlesi Malaria in Humans and Macaques, Thailand Jongwutiwes, Somchai Buppan, Pattakorn Kosuvin, Rattiporn Seethamchai, Sunee Pattanawong, Urassaya Sirichaisinthop, Jeeraphat Putaporntip, Chaturong Emerg Infect Dis Research Naturally acquired human infections with Plasmodium knowlesi are endemic to Southeast Asia. To determine the prevalence of P. knowlesi malaria in malaria-endemic areas of Thailand, we analyzed genetic characteristics of P. knowlesi circulating among naturally infected macaques and humans. This study in 2008–2009 and retrospective analysis of malaria species in human blood samples obtained in 1996 from 1 of these areas showed that P. knowlesi accounted for 0.67% and 0.48% of human malaria cases, respectively, indicating that this simian parasite is not a newly emergent human pathogen in Thailand. Sequence analysis of the complete merozoite surface protein 1 gene of P. knowlesi from 10 human and 5 macaque blood samples showed considerable genetic diversity among isolates. The sequence from 1 patient was identical with that from a pig-tailed macaque living in the same locality, suggesting cross-transmission of P. knowlesi from naturally infected macaques to humans. Centers for Disease Control and Prevention 2011-10 /pmc/articles/PMC3310673/ /pubmed/22000348 http://dx.doi.org/10.3201/eid1710.110349 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Jongwutiwes, Somchai
Buppan, Pattakorn
Kosuvin, Rattiporn
Seethamchai, Sunee
Pattanawong, Urassaya
Sirichaisinthop, Jeeraphat
Putaporntip, Chaturong
Plasmodium knowlesi Malaria in Humans and Macaques, Thailand
title Plasmodium knowlesi Malaria in Humans and Macaques, Thailand
title_full Plasmodium knowlesi Malaria in Humans and Macaques, Thailand
title_fullStr Plasmodium knowlesi Malaria in Humans and Macaques, Thailand
title_full_unstemmed Plasmodium knowlesi Malaria in Humans and Macaques, Thailand
title_short Plasmodium knowlesi Malaria in Humans and Macaques, Thailand
title_sort plasmodium knowlesi malaria in humans and macaques, thailand
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310673/
https://www.ncbi.nlm.nih.gov/pubmed/22000348
http://dx.doi.org/10.3201/eid1710.110349
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