Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy

BACKGROUND: Spinal muscular atrophy (SMA) is the leading genetic cause of infant death. It is caused by mutations/deletions of the survival motor neuron 1 (SMN1) gene and is typified by the loss of spinal cord motor neurons, muscular atrophy, and in severe cases, death. The SMN protein is ubiquitous...

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Detalles Bibliográficos
Autores principales: Bowerman, Melissa, Murray, Lyndsay M, Boyer, Justin G, Anderson, Carrie L, Kothary, Rashmi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310724/
https://www.ncbi.nlm.nih.gov/pubmed/22397316
http://dx.doi.org/10.1186/1741-7015-10-24

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