RUNX3 Mediates Suppression of Tumor Growth and Metastasis of Human CCRCC by Regulating Cyclin Related Proteins and TIMP-1

Here we presented that the expression of RUNX3 was significantly decreased in 75 cases of clear cell renal cell carcinoma (CCRCC) tissues (p<0.05). Enforced RUNX3 expression mediated 786-O cells to exhibit inhibition of growth, G1 cell-cycle arrest and metastasis in vitro, and to lost tumorigenic...

Descripción completa

Detalles Bibliográficos
Autores principales: He, Lijie, Zhao, Xiaodi, Wang, Hanmin, Zhang, Peng, Guo, Changcun, Huang, Chen, Liu, Xiaowei, Yao, Fangfang, Chen, Yu, Lou, Weijuan, Sun, Shiren, Fan, Daiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310845/
https://www.ncbi.nlm.nih.gov/pubmed/22457727
http://dx.doi.org/10.1371/journal.pone.0032961
_version_ 1782227715096576000
author He, Lijie
Zhao, Xiaodi
Wang, Hanmin
Zhang, Peng
Guo, Changcun
Huang, Chen
Liu, Xiaowei
Yao, Fangfang
Chen, Yu
Lou, Weijuan
Sun, Shiren
Fan, Daiming
author_facet He, Lijie
Zhao, Xiaodi
Wang, Hanmin
Zhang, Peng
Guo, Changcun
Huang, Chen
Liu, Xiaowei
Yao, Fangfang
Chen, Yu
Lou, Weijuan
Sun, Shiren
Fan, Daiming
author_sort He, Lijie
collection PubMed
description Here we presented that the expression of RUNX3 was significantly decreased in 75 cases of clear cell renal cell carcinoma (CCRCC) tissues (p<0.05). Enforced RUNX3 expression mediated 786-O cells to exhibit inhibition of growth, G1 cell-cycle arrest and metastasis in vitro, and to lost tumorigenicity in nude mouse model in vivo. RUNX3-induced growth suppression was found partially to regulate various proteins, including inhibition of cyclinD1, cyclinE, cdk2, cdk4 and p-Rb, but increase of p27(Kip1), Rb and TIMP-1. Therefore, RUNX3 had the function of inhibiting the proliferative and metastatic abilities of CCRCC cells by regulating cyclins and TIMP1.
format Online
Article
Text
id pubmed-3310845
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-33108452012-03-28 RUNX3 Mediates Suppression of Tumor Growth and Metastasis of Human CCRCC by Regulating Cyclin Related Proteins and TIMP-1 He, Lijie Zhao, Xiaodi Wang, Hanmin Zhang, Peng Guo, Changcun Huang, Chen Liu, Xiaowei Yao, Fangfang Chen, Yu Lou, Weijuan Sun, Shiren Fan, Daiming PLoS One Research Article Here we presented that the expression of RUNX3 was significantly decreased in 75 cases of clear cell renal cell carcinoma (CCRCC) tissues (p<0.05). Enforced RUNX3 expression mediated 786-O cells to exhibit inhibition of growth, G1 cell-cycle arrest and metastasis in vitro, and to lost tumorigenicity in nude mouse model in vivo. RUNX3-induced growth suppression was found partially to regulate various proteins, including inhibition of cyclinD1, cyclinE, cdk2, cdk4 and p-Rb, but increase of p27(Kip1), Rb and TIMP-1. Therefore, RUNX3 had the function of inhibiting the proliferative and metastatic abilities of CCRCC cells by regulating cyclins and TIMP1. Public Library of Science 2012-03-22 /pmc/articles/PMC3310845/ /pubmed/22457727 http://dx.doi.org/10.1371/journal.pone.0032961 Text en He et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
He, Lijie
Zhao, Xiaodi
Wang, Hanmin
Zhang, Peng
Guo, Changcun
Huang, Chen
Liu, Xiaowei
Yao, Fangfang
Chen, Yu
Lou, Weijuan
Sun, Shiren
Fan, Daiming
RUNX3 Mediates Suppression of Tumor Growth and Metastasis of Human CCRCC by Regulating Cyclin Related Proteins and TIMP-1
title RUNX3 Mediates Suppression of Tumor Growth and Metastasis of Human CCRCC by Regulating Cyclin Related Proteins and TIMP-1
title_full RUNX3 Mediates Suppression of Tumor Growth and Metastasis of Human CCRCC by Regulating Cyclin Related Proteins and TIMP-1
title_fullStr RUNX3 Mediates Suppression of Tumor Growth and Metastasis of Human CCRCC by Regulating Cyclin Related Proteins and TIMP-1
title_full_unstemmed RUNX3 Mediates Suppression of Tumor Growth and Metastasis of Human CCRCC by Regulating Cyclin Related Proteins and TIMP-1
title_short RUNX3 Mediates Suppression of Tumor Growth and Metastasis of Human CCRCC by Regulating Cyclin Related Proteins and TIMP-1
title_sort runx3 mediates suppression of tumor growth and metastasis of human ccrcc by regulating cyclin related proteins and timp-1
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310845/
https://www.ncbi.nlm.nih.gov/pubmed/22457727
http://dx.doi.org/10.1371/journal.pone.0032961
work_keys_str_mv AT helijie runx3mediatessuppressionoftumorgrowthandmetastasisofhumanccrccbyregulatingcyclinrelatedproteinsandtimp1
AT zhaoxiaodi runx3mediatessuppressionoftumorgrowthandmetastasisofhumanccrccbyregulatingcyclinrelatedproteinsandtimp1
AT wanghanmin runx3mediatessuppressionoftumorgrowthandmetastasisofhumanccrccbyregulatingcyclinrelatedproteinsandtimp1
AT zhangpeng runx3mediatessuppressionoftumorgrowthandmetastasisofhumanccrccbyregulatingcyclinrelatedproteinsandtimp1
AT guochangcun runx3mediatessuppressionoftumorgrowthandmetastasisofhumanccrccbyregulatingcyclinrelatedproteinsandtimp1
AT huangchen runx3mediatessuppressionoftumorgrowthandmetastasisofhumanccrccbyregulatingcyclinrelatedproteinsandtimp1
AT liuxiaowei runx3mediatessuppressionoftumorgrowthandmetastasisofhumanccrccbyregulatingcyclinrelatedproteinsandtimp1
AT yaofangfang runx3mediatessuppressionoftumorgrowthandmetastasisofhumanccrccbyregulatingcyclinrelatedproteinsandtimp1
AT chenyu runx3mediatessuppressionoftumorgrowthandmetastasisofhumanccrccbyregulatingcyclinrelatedproteinsandtimp1
AT louweijuan runx3mediatessuppressionoftumorgrowthandmetastasisofhumanccrccbyregulatingcyclinrelatedproteinsandtimp1
AT sunshiren runx3mediatessuppressionoftumorgrowthandmetastasisofhumanccrccbyregulatingcyclinrelatedproteinsandtimp1
AT fandaiming runx3mediatessuppressionoftumorgrowthandmetastasisofhumanccrccbyregulatingcyclinrelatedproteinsandtimp1

Ejemplares similares