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Hypoxic activation of ATR and the suppression of the initiation of DNA replication through cdc6 degradation
Many severely hypoxic cells fail to initiate DNA replication, but the mechanism underlying this observation is unknown. Specifically, while the ataxia-telangiectasia-rad3 related (ATR) kinase has been shown to be activated in hypoxic cells, several studies have not been able to document down-stream...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310967/ https://www.ncbi.nlm.nih.gov/pubmed/22179839 http://dx.doi.org/10.1038/onc.2011.585 |