Carbon Nanotube Thin Film Biosensors for Sensitive and Reproducible Whole Virus Detection

Here, we report the label-free, sensitive, and real-time electrical detection of whole viruses using carbon nanotube thin film (CNT-TF) field effect devices. Selective detection of approximately 550 model viruses, M13-bacteriophage, is demonstrated using a simple two-terminal (no gate electrode) con...

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Detalles Bibliográficos
Autores principales: Mandal, Himadri S., Su, Zhengding, Ward, Andrew, Tang, Xiaowu (Shirley)
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2012
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311235/
https://www.ncbi.nlm.nih.gov/pubmed/22448194
http://dx.doi.org/10.7150/thno.3726
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author Mandal, Himadri S.
Su, Zhengding
Ward, Andrew
Tang, Xiaowu (Shirley)
author_facet Mandal, Himadri S.
Su, Zhengding
Ward, Andrew
Tang, Xiaowu (Shirley)
author_sort Mandal, Himadri S.
collection PubMed
description Here, we report the label-free, sensitive, and real-time electrical detection of whole viruses using carbon nanotube thin film (CNT-TF) field effect devices. Selective detection of approximately 550 model viruses, M13-bacteriophage, is demonstrated using a simple two-terminal (no gate electrode) configuration. Chemical gating through specific antibody-virus binding on CNT surface is proposed to be the sensing mechanism. Compared to electrical impedance sensors with identical microelectrode dimensions (no CNT), the CNT-TF sensors exhibit sensitivity 5 orders higher. We believe the reported approach could lead to a reproducible and cost-effective solution for rapid viral identification.
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spelling pubmed-33112352012-03-23 Carbon Nanotube Thin Film Biosensors for Sensitive and Reproducible Whole Virus Detection Mandal, Himadri S. Su, Zhengding Ward, Andrew Tang, Xiaowu (Shirley) Theranostics Research Paper Here, we report the label-free, sensitive, and real-time electrical detection of whole viruses using carbon nanotube thin film (CNT-TF) field effect devices. Selective detection of approximately 550 model viruses, M13-bacteriophage, is demonstrated using a simple two-terminal (no gate electrode) configuration. Chemical gating through specific antibody-virus binding on CNT surface is proposed to be the sensing mechanism. Compared to electrical impedance sensors with identical microelectrode dimensions (no CNT), the CNT-TF sensors exhibit sensitivity 5 orders higher. We believe the reported approach could lead to a reproducible and cost-effective solution for rapid viral identification. Ivyspring International Publisher 2012-03-01 /pmc/articles/PMC3311235/ /pubmed/22448194 http://dx.doi.org/10.7150/thno.3726 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Research Paper
Mandal, Himadri S.
Su, Zhengding
Ward, Andrew
Tang, Xiaowu (Shirley)
Carbon Nanotube Thin Film Biosensors for Sensitive and Reproducible Whole Virus Detection
title Carbon Nanotube Thin Film Biosensors for Sensitive and Reproducible Whole Virus Detection
title_full Carbon Nanotube Thin Film Biosensors for Sensitive and Reproducible Whole Virus Detection
title_fullStr Carbon Nanotube Thin Film Biosensors for Sensitive and Reproducible Whole Virus Detection
title_full_unstemmed Carbon Nanotube Thin Film Biosensors for Sensitive and Reproducible Whole Virus Detection
title_short Carbon Nanotube Thin Film Biosensors for Sensitive and Reproducible Whole Virus Detection
title_sort carbon nanotube thin film biosensors for sensitive and reproducible whole virus detection
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311235/
https://www.ncbi.nlm.nih.gov/pubmed/22448194
http://dx.doi.org/10.7150/thno.3726
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AT wardandrew carbonnanotubethinfilmbiosensorsforsensitiveandreproduciblewholevirusdetection
AT tangxiaowushirley carbonnanotubethinfilmbiosensorsforsensitiveandreproduciblewholevirusdetection

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