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Effect of Escitalopram on White Blood Cells in Patients With Major Depression

BACKGROUND: Immunological dysfunctions in the course of depression are recently intensively investigated. Pharmacotherapy of depression is speculated to affect immune response. In this study, our objective was to investigate whether escitalopram treatment would affect white blood cells in patients w...

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Autores principales: Canan, Fatih, Ataoglu, Ahmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311445/
https://www.ncbi.nlm.nih.gov/pubmed/22481992
http://dx.doi.org/10.4021/jocmr2009.12.1275
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author Canan, Fatih
Ataoglu, Ahmet
author_facet Canan, Fatih
Ataoglu, Ahmet
author_sort Canan, Fatih
collection PubMed
description BACKGROUND: Immunological dysfunctions in the course of depression are recently intensively investigated. Pharmacotherapy of depression is speculated to affect immune response. In this study, our objective was to investigate whether escitalopram treatment would affect white blood cells in patients with major depression. METHODS: Fifteen patients (11 women and 4 men), meeting the criteria for a current episode of major depressive disorder, were participated. White blood cell (WBC), neutrophil (NEUT), lymphocyte (LYMPH), monocyte (MONO), eosinophyl (EO), and basophyl (BASO) levels were measured at the entry to the study. After 8 weeks of open-label treatment with the selective serotonin reuptake inhibitor escitalopram (10-20 mg/d), the patients were readmitted and the measurements were repeated. RESULTS: At the end of the study, LYMPH was found to be significantly decreased compared to the baseline value after 8 weeks treatment with escitalopram (p < 0.001). There was not a significant change in WBC, NEUT, MONO, EO, and BASO parameters. CONCLUSIONS: The present study has shown that escitalopram increased LYMPH in patients with major depression according to these results, the possible treatment of depression with escitalopram must be carried out with caution, in patients with immunological disturbances. KEYWORDS: Escitalopram; Major depression; White blood cells
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spelling pubmed-33114452012-04-05 Effect of Escitalopram on White Blood Cells in Patients With Major Depression Canan, Fatih Ataoglu, Ahmet J Clin Med Res Short Communication BACKGROUND: Immunological dysfunctions in the course of depression are recently intensively investigated. Pharmacotherapy of depression is speculated to affect immune response. In this study, our objective was to investigate whether escitalopram treatment would affect white blood cells in patients with major depression. METHODS: Fifteen patients (11 women and 4 men), meeting the criteria for a current episode of major depressive disorder, were participated. White blood cell (WBC), neutrophil (NEUT), lymphocyte (LYMPH), monocyte (MONO), eosinophyl (EO), and basophyl (BASO) levels were measured at the entry to the study. After 8 weeks of open-label treatment with the selective serotonin reuptake inhibitor escitalopram (10-20 mg/d), the patients were readmitted and the measurements were repeated. RESULTS: At the end of the study, LYMPH was found to be significantly decreased compared to the baseline value after 8 weeks treatment with escitalopram (p < 0.001). There was not a significant change in WBC, NEUT, MONO, EO, and BASO parameters. CONCLUSIONS: The present study has shown that escitalopram increased LYMPH in patients with major depression according to these results, the possible treatment of depression with escitalopram must be carried out with caution, in patients with immunological disturbances. KEYWORDS: Escitalopram; Major depression; White blood cells Elmer Press 2009-12 2009-12-28 /pmc/articles/PMC3311445/ /pubmed/22481992 http://dx.doi.org/10.4021/jocmr2009.12.1275 Text en Copyright 2009, Canan et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Canan, Fatih
Ataoglu, Ahmet
Effect of Escitalopram on White Blood Cells in Patients With Major Depression
title Effect of Escitalopram on White Blood Cells in Patients With Major Depression
title_full Effect of Escitalopram on White Blood Cells in Patients With Major Depression
title_fullStr Effect of Escitalopram on White Blood Cells in Patients With Major Depression
title_full_unstemmed Effect of Escitalopram on White Blood Cells in Patients With Major Depression
title_short Effect of Escitalopram on White Blood Cells in Patients With Major Depression
title_sort effect of escitalopram on white blood cells in patients with major depression
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311445/
https://www.ncbi.nlm.nih.gov/pubmed/22481992
http://dx.doi.org/10.4021/jocmr2009.12.1275
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