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Effect of Escitalopram on White Blood Cells in Patients With Major Depression
BACKGROUND: Immunological dysfunctions in the course of depression are recently intensively investigated. Pharmacotherapy of depression is speculated to affect immune response. In this study, our objective was to investigate whether escitalopram treatment would affect white blood cells in patients w...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elmer Press
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311445/ https://www.ncbi.nlm.nih.gov/pubmed/22481992 http://dx.doi.org/10.4021/jocmr2009.12.1275 |
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author | Canan, Fatih Ataoglu, Ahmet |
author_facet | Canan, Fatih Ataoglu, Ahmet |
author_sort | Canan, Fatih |
collection | PubMed |
description | BACKGROUND: Immunological dysfunctions in the course of depression are recently intensively investigated. Pharmacotherapy of depression is speculated to affect immune response. In this study, our objective was to investigate whether escitalopram treatment would affect white blood cells in patients with major depression. METHODS: Fifteen patients (11 women and 4 men), meeting the criteria for a current episode of major depressive disorder, were participated. White blood cell (WBC), neutrophil (NEUT), lymphocyte (LYMPH), monocyte (MONO), eosinophyl (EO), and basophyl (BASO) levels were measured at the entry to the study. After 8 weeks of open-label treatment with the selective serotonin reuptake inhibitor escitalopram (10-20 mg/d), the patients were readmitted and the measurements were repeated. RESULTS: At the end of the study, LYMPH was found to be significantly decreased compared to the baseline value after 8 weeks treatment with escitalopram (p < 0.001). There was not a significant change in WBC, NEUT, MONO, EO, and BASO parameters. CONCLUSIONS: The present study has shown that escitalopram increased LYMPH in patients with major depression according to these results, the possible treatment of depression with escitalopram must be carried out with caution, in patients with immunological disturbances. KEYWORDS: Escitalopram; Major depression; White blood cells |
format | Online Article Text |
id | pubmed-3311445 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Elmer Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-33114452012-04-05 Effect of Escitalopram on White Blood Cells in Patients With Major Depression Canan, Fatih Ataoglu, Ahmet J Clin Med Res Short Communication BACKGROUND: Immunological dysfunctions in the course of depression are recently intensively investigated. Pharmacotherapy of depression is speculated to affect immune response. In this study, our objective was to investigate whether escitalopram treatment would affect white blood cells in patients with major depression. METHODS: Fifteen patients (11 women and 4 men), meeting the criteria for a current episode of major depressive disorder, were participated. White blood cell (WBC), neutrophil (NEUT), lymphocyte (LYMPH), monocyte (MONO), eosinophyl (EO), and basophyl (BASO) levels were measured at the entry to the study. After 8 weeks of open-label treatment with the selective serotonin reuptake inhibitor escitalopram (10-20 mg/d), the patients were readmitted and the measurements were repeated. RESULTS: At the end of the study, LYMPH was found to be significantly decreased compared to the baseline value after 8 weeks treatment with escitalopram (p < 0.001). There was not a significant change in WBC, NEUT, MONO, EO, and BASO parameters. CONCLUSIONS: The present study has shown that escitalopram increased LYMPH in patients with major depression according to these results, the possible treatment of depression with escitalopram must be carried out with caution, in patients with immunological disturbances. KEYWORDS: Escitalopram; Major depression; White blood cells Elmer Press 2009-12 2009-12-28 /pmc/articles/PMC3311445/ /pubmed/22481992 http://dx.doi.org/10.4021/jocmr2009.12.1275 Text en Copyright 2009, Canan et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Canan, Fatih Ataoglu, Ahmet Effect of Escitalopram on White Blood Cells in Patients With Major Depression |
title | Effect of Escitalopram on White Blood Cells in Patients With Major Depression |
title_full | Effect of Escitalopram on White Blood Cells in Patients With Major Depression |
title_fullStr | Effect of Escitalopram on White Blood Cells in Patients With Major Depression |
title_full_unstemmed | Effect of Escitalopram on White Blood Cells in Patients With Major Depression |
title_short | Effect of Escitalopram on White Blood Cells in Patients With Major Depression |
title_sort | effect of escitalopram on white blood cells in patients with major depression |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311445/ https://www.ncbi.nlm.nih.gov/pubmed/22481992 http://dx.doi.org/10.4021/jocmr2009.12.1275 |
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