Kindlins, Integrin Activation and the Regulation of Talin Recruitment to αIIbβ3

Talins and kindlins bind to the integrin β3 cytoplasmic tail and both are required for effective activation of integrin αIIbβ3 and resulting high-affinity ligand binding in platelets. However, binding of the talin head domain alone to β3 is sufficient to activate purified integrin αIIbβ3 in vitro. S...

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Detalles Bibliográficos
Autores principales: Kahner, Bryan N., Kato, Hisashi, Banno, Asoka, Ginsberg, Mark H., Shattil, Sanford J., Ye, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311585/
https://www.ncbi.nlm.nih.gov/pubmed/22457811
http://dx.doi.org/10.1371/journal.pone.0034056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311585/
https://www.ncbi.nlm.nih.gov/pubmed/22457811
http://dx.doi.org/10.1371/journal.pone.0034056

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