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Synergistic Effect of Hyperglycemia and p27(kip1) Suppression on Adult Mouse Islet Beta Cell Replication

The complementary role of hyperglycemia and p27(kip1) suppression on islet beta cell regeneration was investigated in a syngeneic mouse model. p27(kip1) gene silencing was performed by infecting islets of C57BL/6 with shRNA lentiviral particles. At 54 hours after viral infection, p27(kip1) protein c...

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Detalles Bibliográficos
Autores principales:	Chen, Szu-Tah, Fu, Shin-Huei, Hsu, Samuel, Huang, Yu-Yao, Hsu, Brend Ray-Sea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312240/ https://www.ncbi.nlm.nih.gov/pubmed/22505890 http://dx.doi.org/10.1155/2012/417390

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