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Aging Phenotypes of Common Marmosets (Callithrix jacchus)
Characterizing the phenotypic changes associated with aging in a short-lived primate is necessary in order to develop better translational models for human health, aging, and disease research. A population of conventionally housed marmoset monkeys was assessed to determine if phenotypes of body comp...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312272/ https://www.ncbi.nlm.nih.gov/pubmed/22506113 http://dx.doi.org/10.1155/2012/567143 |
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author | Ross, Corinna N. Davis, Kenneth Dobek, Georgina Tardif, Suzette D. |
author_facet | Ross, Corinna N. Davis, Kenneth Dobek, Georgina Tardif, Suzette D. |
author_sort | Ross, Corinna N. |
collection | PubMed |
description | Characterizing the phenotypic changes associated with aging in a short-lived primate is necessary in order to develop better translational models for human health, aging, and disease research. A population of conventionally housed marmoset monkeys was assessed to determine if phenotypes of body composition, hematology, and morphometrical measures were associated with age or risk of death. We found that the cause of mortality in older marmosets was more likely to be due to cardiac and chronic kidney disease than in younger marmosets. Older marmosets have decreased fat mass, morphometric measures, and serum albumin. Older marmosets are more likely to show a modified posture while at rest and this modified posture was significantly associated with an increased risk of imminent death. These assessments provide an initial definition of aged health in marmosets and a base for future translational aging research with this species. |
format | Online Article Text |
id | pubmed-3312272 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33122722012-04-13 Aging Phenotypes of Common Marmosets (Callithrix jacchus) Ross, Corinna N. Davis, Kenneth Dobek, Georgina Tardif, Suzette D. J Aging Res Research Article Characterizing the phenotypic changes associated with aging in a short-lived primate is necessary in order to develop better translational models for human health, aging, and disease research. A population of conventionally housed marmoset monkeys was assessed to determine if phenotypes of body composition, hematology, and morphometrical measures were associated with age or risk of death. We found that the cause of mortality in older marmosets was more likely to be due to cardiac and chronic kidney disease than in younger marmosets. Older marmosets have decreased fat mass, morphometric measures, and serum albumin. Older marmosets are more likely to show a modified posture while at rest and this modified posture was significantly associated with an increased risk of imminent death. These assessments provide an initial definition of aged health in marmosets and a base for future translational aging research with this species. Hindawi Publishing Corporation 2012 2012-03-04 /pmc/articles/PMC3312272/ /pubmed/22506113 http://dx.doi.org/10.1155/2012/567143 Text en Copyright © 2012 Corinna N. Ross et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Ross, Corinna N. Davis, Kenneth Dobek, Georgina Tardif, Suzette D. Aging Phenotypes of Common Marmosets (Callithrix jacchus) |
title | Aging Phenotypes of Common Marmosets (Callithrix jacchus) |
title_full | Aging Phenotypes of Common Marmosets (Callithrix jacchus) |
title_fullStr | Aging Phenotypes of Common Marmosets (Callithrix jacchus) |
title_full_unstemmed | Aging Phenotypes of Common Marmosets (Callithrix jacchus) |
title_short | Aging Phenotypes of Common Marmosets (Callithrix jacchus) |
title_sort | aging phenotypes of common marmosets (callithrix jacchus) |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312272/ https://www.ncbi.nlm.nih.gov/pubmed/22506113 http://dx.doi.org/10.1155/2012/567143 |
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