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Aging Phenotypes of Common Marmosets (Callithrix jacchus)

Characterizing the phenotypic changes associated with aging in a short-lived primate is necessary in order to develop better translational models for human health, aging, and disease research. A population of conventionally housed marmoset monkeys was assessed to determine if phenotypes of body comp...

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Autores principales: Ross, Corinna N., Davis, Kenneth, Dobek, Georgina, Tardif, Suzette D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312272/
https://www.ncbi.nlm.nih.gov/pubmed/22506113
http://dx.doi.org/10.1155/2012/567143
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author Ross, Corinna N.
Davis, Kenneth
Dobek, Georgina
Tardif, Suzette D.
author_facet Ross, Corinna N.
Davis, Kenneth
Dobek, Georgina
Tardif, Suzette D.
author_sort Ross, Corinna N.
collection PubMed
description Characterizing the phenotypic changes associated with aging in a short-lived primate is necessary in order to develop better translational models for human health, aging, and disease research. A population of conventionally housed marmoset monkeys was assessed to determine if phenotypes of body composition, hematology, and morphometrical measures were associated with age or risk of death. We found that the cause of mortality in older marmosets was more likely to be due to cardiac and chronic kidney disease than in younger marmosets. Older marmosets have decreased fat mass, morphometric measures, and serum albumin. Older marmosets are more likely to show a modified posture while at rest and this modified posture was significantly associated with an increased risk of imminent death. These assessments provide an initial definition of aged health in marmosets and a base for future translational aging research with this species.
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spelling pubmed-33122722012-04-13 Aging Phenotypes of Common Marmosets (Callithrix jacchus) Ross, Corinna N. Davis, Kenneth Dobek, Georgina Tardif, Suzette D. J Aging Res Research Article Characterizing the phenotypic changes associated with aging in a short-lived primate is necessary in order to develop better translational models for human health, aging, and disease research. A population of conventionally housed marmoset monkeys was assessed to determine if phenotypes of body composition, hematology, and morphometrical measures were associated with age or risk of death. We found that the cause of mortality in older marmosets was more likely to be due to cardiac and chronic kidney disease than in younger marmosets. Older marmosets have decreased fat mass, morphometric measures, and serum albumin. Older marmosets are more likely to show a modified posture while at rest and this modified posture was significantly associated with an increased risk of imminent death. These assessments provide an initial definition of aged health in marmosets and a base for future translational aging research with this species. Hindawi Publishing Corporation 2012 2012-03-04 /pmc/articles/PMC3312272/ /pubmed/22506113 http://dx.doi.org/10.1155/2012/567143 Text en Copyright © 2012 Corinna N. Ross et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ross, Corinna N.
Davis, Kenneth
Dobek, Georgina
Tardif, Suzette D.
Aging Phenotypes of Common Marmosets (Callithrix jacchus)
title Aging Phenotypes of Common Marmosets (Callithrix jacchus)
title_full Aging Phenotypes of Common Marmosets (Callithrix jacchus)
title_fullStr Aging Phenotypes of Common Marmosets (Callithrix jacchus)
title_full_unstemmed Aging Phenotypes of Common Marmosets (Callithrix jacchus)
title_short Aging Phenotypes of Common Marmosets (Callithrix jacchus)
title_sort aging phenotypes of common marmosets (callithrix jacchus)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312272/
https://www.ncbi.nlm.nih.gov/pubmed/22506113
http://dx.doi.org/10.1155/2012/567143
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