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Circadian rhythms and memory formation: regulation by chromatin remodeling

Epigenetic changes, such as DNA methylation or histone modification, can remodel the chromatin and regulate gene expression. Remodeling of chromatin provides an efficient mechanism of transducing signals, such as light or nutrient availability, to regulate gene expression. CLOCK:BMAL1 mediated activ...

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Detalles Bibliográficos
Autores principales: Sahar, Saurabh, Sassone-Corsi, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312286/
https://www.ncbi.nlm.nih.gov/pubmed/22470318
http://dx.doi.org/10.3389/fnmol.2012.00037
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author Sahar, Saurabh
Sassone-Corsi, Paolo
author_facet Sahar, Saurabh
Sassone-Corsi, Paolo
author_sort Sahar, Saurabh
collection PubMed
description Epigenetic changes, such as DNA methylation or histone modification, can remodel the chromatin and regulate gene expression. Remodeling of chromatin provides an efficient mechanism of transducing signals, such as light or nutrient availability, to regulate gene expression. CLOCK:BMAL1 mediated activation of clock-controlled genes (CCGs) is coupled to circadian changes in histone modification at their promoters. Several chromatin modifiers, such as the deacetylases SIRT1 and HDAC3 or methyltransferase MLL1, have been shown to be recruited to the promoters of the CCGs in a circadian manner. Interestingly, the central element of the core clock machinery, the transcription factor CLOCK, also possesses histone acetyltransferase activity. Rhythmic expression of the CCGs is abolished in the absence of these chromatin modifiers. Recent research has demonstrated that chromatin remodeling is at the cross-roads of circadian rhythms and regulation of metabolism and aging. It would be of interest to identify if similar pathways exist in the epigenetic regulation of memory formation.
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spelling pubmed-33122862012-04-02 Circadian rhythms and memory formation: regulation by chromatin remodeling Sahar, Saurabh Sassone-Corsi, Paolo Front Mol Neurosci Neuroscience Epigenetic changes, such as DNA methylation or histone modification, can remodel the chromatin and regulate gene expression. Remodeling of chromatin provides an efficient mechanism of transducing signals, such as light or nutrient availability, to regulate gene expression. CLOCK:BMAL1 mediated activation of clock-controlled genes (CCGs) is coupled to circadian changes in histone modification at their promoters. Several chromatin modifiers, such as the deacetylases SIRT1 and HDAC3 or methyltransferase MLL1, have been shown to be recruited to the promoters of the CCGs in a circadian manner. Interestingly, the central element of the core clock machinery, the transcription factor CLOCK, also possesses histone acetyltransferase activity. Rhythmic expression of the CCGs is abolished in the absence of these chromatin modifiers. Recent research has demonstrated that chromatin remodeling is at the cross-roads of circadian rhythms and regulation of metabolism and aging. It would be of interest to identify if similar pathways exist in the epigenetic regulation of memory formation. Frontiers Research Foundation 2012-03-26 /pmc/articles/PMC3312286/ /pubmed/22470318 http://dx.doi.org/10.3389/fnmol.2012.00037 Text en Copyright © 2012 Sahar and Sassone-Corsi. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) , which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Neuroscience
Sahar, Saurabh
Sassone-Corsi, Paolo
Circadian rhythms and memory formation: regulation by chromatin remodeling
title Circadian rhythms and memory formation: regulation by chromatin remodeling
title_full Circadian rhythms and memory formation: regulation by chromatin remodeling
title_fullStr Circadian rhythms and memory formation: regulation by chromatin remodeling
title_full_unstemmed Circadian rhythms and memory formation: regulation by chromatin remodeling
title_short Circadian rhythms and memory formation: regulation by chromatin remodeling
title_sort circadian rhythms and memory formation: regulation by chromatin remodeling
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312286/
https://www.ncbi.nlm.nih.gov/pubmed/22470318
http://dx.doi.org/10.3389/fnmol.2012.00037
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