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Age-Related Loss of Muscle Mass and Strength

Age-related muscle wasting and increased frailty are major socioeconomic as well as medical problems. In the quest to extend quality of life it is important to increase the strength of elderly people sufficiently so they can carry out everyday tasks and to prevent them falling and breaking bones tha...

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Detalles Bibliográficos
Autor principal: Goldspink, Geoffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312297/
https://www.ncbi.nlm.nih.gov/pubmed/22506111
http://dx.doi.org/10.1155/2012/158279
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author Goldspink, Geoffrey
author_facet Goldspink, Geoffrey
author_sort Goldspink, Geoffrey
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description Age-related muscle wasting and increased frailty are major socioeconomic as well as medical problems. In the quest to extend quality of life it is important to increase the strength of elderly people sufficiently so they can carry out everyday tasks and to prevent them falling and breaking bones that are brittle due to osteoporosis. Muscles generate the mechanical strain that contributes to the maintenance of other musculoskeletal tissues, and a vicious circle is established as muscle loss results in bone loss and weakening of tendons. Molecular and proteomic approaches now provide strategies for preventing age-related muscle wasting. Here, attention is paid to the role of the GH/IGF-1 axis and the special role of the IGFI-Ec (mechano growth factor/MGF) which is derived from the IGF-I gene by alternative splicing. During aging MGF levels decline but when administered MGF activates the muscle satellite (stem) cells that “kick start” local muscle repair and induces hypertrophy.
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spelling pubmed-33122972012-04-13 Age-Related Loss of Muscle Mass and Strength Goldspink, Geoffrey J Aging Res Review Article Age-related muscle wasting and increased frailty are major socioeconomic as well as medical problems. In the quest to extend quality of life it is important to increase the strength of elderly people sufficiently so they can carry out everyday tasks and to prevent them falling and breaking bones that are brittle due to osteoporosis. Muscles generate the mechanical strain that contributes to the maintenance of other musculoskeletal tissues, and a vicious circle is established as muscle loss results in bone loss and weakening of tendons. Molecular and proteomic approaches now provide strategies for preventing age-related muscle wasting. Here, attention is paid to the role of the GH/IGF-1 axis and the special role of the IGFI-Ec (mechano growth factor/MGF) which is derived from the IGF-I gene by alternative splicing. During aging MGF levels decline but when administered MGF activates the muscle satellite (stem) cells that “kick start” local muscle repair and induces hypertrophy. Hindawi Publishing Corporation 2012 2012-03-08 /pmc/articles/PMC3312297/ /pubmed/22506111 http://dx.doi.org/10.1155/2012/158279 Text en Copyright © 2012 Geoffrey Goldspink. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Goldspink, Geoffrey
Age-Related Loss of Muscle Mass and Strength
title Age-Related Loss of Muscle Mass and Strength
title_full Age-Related Loss of Muscle Mass and Strength
title_fullStr Age-Related Loss of Muscle Mass and Strength
title_full_unstemmed Age-Related Loss of Muscle Mass and Strength
title_short Age-Related Loss of Muscle Mass and Strength
title_sort age-related loss of muscle mass and strength
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312297/
https://www.ncbi.nlm.nih.gov/pubmed/22506111
http://dx.doi.org/10.1155/2012/158279
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