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Neuroprotective Effect of Phosphocreatine on Focal Cerebral Ischemia-Reperfusion Injury

Phosphocreatine (PCr) is a natural compound, which can donate high-energy phosphate group to ADP to synthesize ATP, even in the absence of oxygen and glucose. At present, it is widely used in cardiac and renal ischemia-reperfusion (IR) disease. In this study, to examine the protective efficacy of PC...

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Detalles Bibliográficos
Autores principales: Li, Tiegang, Wang, Nana, Zhao, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312326/
https://www.ncbi.nlm.nih.gov/pubmed/22505804
http://dx.doi.org/10.1155/2012/168756
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author Li, Tiegang
Wang, Nana
Zhao, Min
author_facet Li, Tiegang
Wang, Nana
Zhao, Min
author_sort Li, Tiegang
collection PubMed
description Phosphocreatine (PCr) is a natural compound, which can donate high-energy phosphate group to ADP to synthesize ATP, even in the absence of oxygen and glucose. At present, it is widely used in cardiac and renal ischemia-reperfusion (IR) disease. In this study, to examine the protective efficacy of PCr against cerebral IR, disodium creatine phosphate was injected intravenously into rats before focal cerebral IR. Intracranial pressure (ICP), neurological score, cerebral infarction volume, and apoptotic neurons were observed. Expression of caspase-3 and aquaporin-4 (AQP4) was analyzed. Compared with IR group, rats pretreated with PCr had better neurologic score, less infarction volume, fewer ultrastructural histopathologic changes, reduced apoptosis, and lower aquaporin-4 level. In conclusion, PCr is neuroprotective after transient focal cerebral IR injury. Such a protection might be associated with apoptosis regulating proteins.
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spelling pubmed-33123262012-04-13 Neuroprotective Effect of Phosphocreatine on Focal Cerebral Ischemia-Reperfusion Injury Li, Tiegang Wang, Nana Zhao, Min J Biomed Biotechnol Research Article Phosphocreatine (PCr) is a natural compound, which can donate high-energy phosphate group to ADP to synthesize ATP, even in the absence of oxygen and glucose. At present, it is widely used in cardiac and renal ischemia-reperfusion (IR) disease. In this study, to examine the protective efficacy of PCr against cerebral IR, disodium creatine phosphate was injected intravenously into rats before focal cerebral IR. Intracranial pressure (ICP), neurological score, cerebral infarction volume, and apoptotic neurons were observed. Expression of caspase-3 and aquaporin-4 (AQP4) was analyzed. Compared with IR group, rats pretreated with PCr had better neurologic score, less infarction volume, fewer ultrastructural histopathologic changes, reduced apoptosis, and lower aquaporin-4 level. In conclusion, PCr is neuroprotective after transient focal cerebral IR injury. Such a protection might be associated with apoptosis regulating proteins. Hindawi Publishing Corporation 2012 2012-03-13 /pmc/articles/PMC3312326/ /pubmed/22505804 http://dx.doi.org/10.1155/2012/168756 Text en Copyright © 2012 Tiegang Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Li, Tiegang
Wang, Nana
Zhao, Min
Neuroprotective Effect of Phosphocreatine on Focal Cerebral Ischemia-Reperfusion Injury
title Neuroprotective Effect of Phosphocreatine on Focal Cerebral Ischemia-Reperfusion Injury
title_full Neuroprotective Effect of Phosphocreatine on Focal Cerebral Ischemia-Reperfusion Injury
title_fullStr Neuroprotective Effect of Phosphocreatine on Focal Cerebral Ischemia-Reperfusion Injury
title_full_unstemmed Neuroprotective Effect of Phosphocreatine on Focal Cerebral Ischemia-Reperfusion Injury
title_short Neuroprotective Effect of Phosphocreatine on Focal Cerebral Ischemia-Reperfusion Injury
title_sort neuroprotective effect of phosphocreatine on focal cerebral ischemia-reperfusion injury
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312326/
https://www.ncbi.nlm.nih.gov/pubmed/22505804
http://dx.doi.org/10.1155/2012/168756
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