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Methylphenidate Exposure Induces Dopamine Neuron Loss and Activation of Microglia in the Basal Ganglia of Mice

BACKGROUND: Methylphenidate (MPH) is a psychostimulant that exerts its pharmacological effects via preferential blockade of the dopamine transporter (DAT) and the norepinephrine transporter (NET), resulting in increased monoamine levels in the synapse. Clinically, methylphenidate is prescribed for t...

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Detalles Bibliográficos
Autores principales:	Sadasivan, Shankar, Pond, Brooks B., Pani, Amar K., Qu, Chunxu, Jiao, Yun, Smeyne, Richard J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312333/ https://www.ncbi.nlm.nih.gov/pubmed/22470460 http://dx.doi.org/10.1371/journal.pone.0033693

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