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Asymmetrical Dimethylarginine - More Sensitive than NT-proBNP to Diagnose Heart Failure in Adults with Congenital Heart Disease
BACKGROUND: Chronic heart failure is an important cause for morbidity and mortality in adults with congenital heart disease (ACHD). While NT-proBNP is an established biomarker for heart failure of non-congenital origin, its value in ACHD has limitations. Asymmetrical dimethylarginine (ADMA) correlat...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312350/ https://www.ncbi.nlm.nih.gov/pubmed/22470476 http://dx.doi.org/10.1371/journal.pone.0033795 |
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author | Tutarel, Oktay Denecke, Agnieszka Bode-Böger, Stefanie M. Martens-Lobenhoffer, Jens Lovric, Svjetlana Bauersachs, Johann Schieffer, Bernhard Westhoff-Bleck, Mechthild Kielstein, Jan T. |
author_facet | Tutarel, Oktay Denecke, Agnieszka Bode-Böger, Stefanie M. Martens-Lobenhoffer, Jens Lovric, Svjetlana Bauersachs, Johann Schieffer, Bernhard Westhoff-Bleck, Mechthild Kielstein, Jan T. |
author_sort | Tutarel, Oktay |
collection | PubMed |
description | BACKGROUND: Chronic heart failure is an important cause for morbidity and mortality in adults with congenital heart disease (ACHD). While NT-proBNP is an established biomarker for heart failure of non-congenital origin, its value in ACHD has limitations. Asymmetrical dimethylarginine (ADMA) correlates with disease severity and independently predicts adverse clinical events in heart failure of non-congenital origin. Its role in ACHD has not been investigated. METHODS: In 102 patients ADMA and NT-proBNP were measured and related to NYHA class, systemic ventricular function and parameters of cardiopulmonary exercise testing. RESULTS: In contrast to NT-proBNP ADMA differentiated between NYHA classes I-III. Both, ADMA and NT-proBNP showed a good correlation with parameters of cardiopulmonary exercise testing with comparable receiver-operating characteristic curves for identifying patients with severely limited cardiopulmonary exercise capacity. CONCLUSION: ADMA seems to be a better biomarker than NT-proBNP for the assessment of NYHA class and as a good as NT-proBNP for the estimation of maximum exercise capacity in adults with congenital heart disease. Its use in clinical routine should be evaluated. |
format | Online Article Text |
id | pubmed-3312350 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-33123502012-04-02 Asymmetrical Dimethylarginine - More Sensitive than NT-proBNP to Diagnose Heart Failure in Adults with Congenital Heart Disease Tutarel, Oktay Denecke, Agnieszka Bode-Böger, Stefanie M. Martens-Lobenhoffer, Jens Lovric, Svjetlana Bauersachs, Johann Schieffer, Bernhard Westhoff-Bleck, Mechthild Kielstein, Jan T. PLoS One Research Article BACKGROUND: Chronic heart failure is an important cause for morbidity and mortality in adults with congenital heart disease (ACHD). While NT-proBNP is an established biomarker for heart failure of non-congenital origin, its value in ACHD has limitations. Asymmetrical dimethylarginine (ADMA) correlates with disease severity and independently predicts adverse clinical events in heart failure of non-congenital origin. Its role in ACHD has not been investigated. METHODS: In 102 patients ADMA and NT-proBNP were measured and related to NYHA class, systemic ventricular function and parameters of cardiopulmonary exercise testing. RESULTS: In contrast to NT-proBNP ADMA differentiated between NYHA classes I-III. Both, ADMA and NT-proBNP showed a good correlation with parameters of cardiopulmonary exercise testing with comparable receiver-operating characteristic curves for identifying patients with severely limited cardiopulmonary exercise capacity. CONCLUSION: ADMA seems to be a better biomarker than NT-proBNP for the assessment of NYHA class and as a good as NT-proBNP for the estimation of maximum exercise capacity in adults with congenital heart disease. Its use in clinical routine should be evaluated. Public Library of Science 2012-03-21 /pmc/articles/PMC3312350/ /pubmed/22470476 http://dx.doi.org/10.1371/journal.pone.0033795 Text en Tutarel et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Tutarel, Oktay Denecke, Agnieszka Bode-Böger, Stefanie M. Martens-Lobenhoffer, Jens Lovric, Svjetlana Bauersachs, Johann Schieffer, Bernhard Westhoff-Bleck, Mechthild Kielstein, Jan T. Asymmetrical Dimethylarginine - More Sensitive than NT-proBNP to Diagnose Heart Failure in Adults with Congenital Heart Disease |
title | Asymmetrical Dimethylarginine - More Sensitive than NT-proBNP to Diagnose Heart Failure in Adults with Congenital Heart Disease |
title_full | Asymmetrical Dimethylarginine - More Sensitive than NT-proBNP to Diagnose Heart Failure in Adults with Congenital Heart Disease |
title_fullStr | Asymmetrical Dimethylarginine - More Sensitive than NT-proBNP to Diagnose Heart Failure in Adults with Congenital Heart Disease |
title_full_unstemmed | Asymmetrical Dimethylarginine - More Sensitive than NT-proBNP to Diagnose Heart Failure in Adults with Congenital Heart Disease |
title_short | Asymmetrical Dimethylarginine - More Sensitive than NT-proBNP to Diagnose Heart Failure in Adults with Congenital Heart Disease |
title_sort | asymmetrical dimethylarginine - more sensitive than nt-probnp to diagnose heart failure in adults with congenital heart disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312350/ https://www.ncbi.nlm.nih.gov/pubmed/22470476 http://dx.doi.org/10.1371/journal.pone.0033795 |
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