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Asymmetrical Dimethylarginine - More Sensitive than NT-proBNP to Diagnose Heart Failure in Adults with Congenital Heart Disease

BACKGROUND: Chronic heart failure is an important cause for morbidity and mortality in adults with congenital heart disease (ACHD). While NT-proBNP is an established biomarker for heart failure of non-congenital origin, its value in ACHD has limitations. Asymmetrical dimethylarginine (ADMA) correlat...

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Autores principales: Tutarel, Oktay, Denecke, Agnieszka, Bode-Böger, Stefanie M., Martens-Lobenhoffer, Jens, Lovric, Svjetlana, Bauersachs, Johann, Schieffer, Bernhard, Westhoff-Bleck, Mechthild, Kielstein, Jan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312350/
https://www.ncbi.nlm.nih.gov/pubmed/22470476
http://dx.doi.org/10.1371/journal.pone.0033795
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author Tutarel, Oktay
Denecke, Agnieszka
Bode-Böger, Stefanie M.
Martens-Lobenhoffer, Jens
Lovric, Svjetlana
Bauersachs, Johann
Schieffer, Bernhard
Westhoff-Bleck, Mechthild
Kielstein, Jan T.
author_facet Tutarel, Oktay
Denecke, Agnieszka
Bode-Böger, Stefanie M.
Martens-Lobenhoffer, Jens
Lovric, Svjetlana
Bauersachs, Johann
Schieffer, Bernhard
Westhoff-Bleck, Mechthild
Kielstein, Jan T.
author_sort Tutarel, Oktay
collection PubMed
description BACKGROUND: Chronic heart failure is an important cause for morbidity and mortality in adults with congenital heart disease (ACHD). While NT-proBNP is an established biomarker for heart failure of non-congenital origin, its value in ACHD has limitations. Asymmetrical dimethylarginine (ADMA) correlates with disease severity and independently predicts adverse clinical events in heart failure of non-congenital origin. Its role in ACHD has not been investigated. METHODS: In 102 patients ADMA and NT-proBNP were measured and related to NYHA class, systemic ventricular function and parameters of cardiopulmonary exercise testing. RESULTS: In contrast to NT-proBNP ADMA differentiated between NYHA classes I-III. Both, ADMA and NT-proBNP showed a good correlation with parameters of cardiopulmonary exercise testing with comparable receiver-operating characteristic curves for identifying patients with severely limited cardiopulmonary exercise capacity. CONCLUSION: ADMA seems to be a better biomarker than NT-proBNP for the assessment of NYHA class and as a good as NT-proBNP for the estimation of maximum exercise capacity in adults with congenital heart disease. Its use in clinical routine should be evaluated.
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spelling pubmed-33123502012-04-02 Asymmetrical Dimethylarginine - More Sensitive than NT-proBNP to Diagnose Heart Failure in Adults with Congenital Heart Disease Tutarel, Oktay Denecke, Agnieszka Bode-Böger, Stefanie M. Martens-Lobenhoffer, Jens Lovric, Svjetlana Bauersachs, Johann Schieffer, Bernhard Westhoff-Bleck, Mechthild Kielstein, Jan T. PLoS One Research Article BACKGROUND: Chronic heart failure is an important cause for morbidity and mortality in adults with congenital heart disease (ACHD). While NT-proBNP is an established biomarker for heart failure of non-congenital origin, its value in ACHD has limitations. Asymmetrical dimethylarginine (ADMA) correlates with disease severity and independently predicts adverse clinical events in heart failure of non-congenital origin. Its role in ACHD has not been investigated. METHODS: In 102 patients ADMA and NT-proBNP were measured and related to NYHA class, systemic ventricular function and parameters of cardiopulmonary exercise testing. RESULTS: In contrast to NT-proBNP ADMA differentiated between NYHA classes I-III. Both, ADMA and NT-proBNP showed a good correlation with parameters of cardiopulmonary exercise testing with comparable receiver-operating characteristic curves for identifying patients with severely limited cardiopulmonary exercise capacity. CONCLUSION: ADMA seems to be a better biomarker than NT-proBNP for the assessment of NYHA class and as a good as NT-proBNP for the estimation of maximum exercise capacity in adults with congenital heart disease. Its use in clinical routine should be evaluated. Public Library of Science 2012-03-21 /pmc/articles/PMC3312350/ /pubmed/22470476 http://dx.doi.org/10.1371/journal.pone.0033795 Text en Tutarel et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Tutarel, Oktay
Denecke, Agnieszka
Bode-Böger, Stefanie M.
Martens-Lobenhoffer, Jens
Lovric, Svjetlana
Bauersachs, Johann
Schieffer, Bernhard
Westhoff-Bleck, Mechthild
Kielstein, Jan T.
Asymmetrical Dimethylarginine - More Sensitive than NT-proBNP to Diagnose Heart Failure in Adults with Congenital Heart Disease
title Asymmetrical Dimethylarginine - More Sensitive than NT-proBNP to Diagnose Heart Failure in Adults with Congenital Heart Disease
title_full Asymmetrical Dimethylarginine - More Sensitive than NT-proBNP to Diagnose Heart Failure in Adults with Congenital Heart Disease
title_fullStr Asymmetrical Dimethylarginine - More Sensitive than NT-proBNP to Diagnose Heart Failure in Adults with Congenital Heart Disease
title_full_unstemmed Asymmetrical Dimethylarginine - More Sensitive than NT-proBNP to Diagnose Heart Failure in Adults with Congenital Heart Disease
title_short Asymmetrical Dimethylarginine - More Sensitive than NT-proBNP to Diagnose Heart Failure in Adults with Congenital Heart Disease
title_sort asymmetrical dimethylarginine - more sensitive than nt-probnp to diagnose heart failure in adults with congenital heart disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312350/
https://www.ncbi.nlm.nih.gov/pubmed/22470476
http://dx.doi.org/10.1371/journal.pone.0033795
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