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Antidiabetic effect of a black mangrove species Aegiceras corniculatum in alloxan-induced diabetic rats
Earlier ethnopharmacological records divulged the traditional usages of mangrove Aegiceras corniculatum (Linn.) Blanco distributed in coastal and estuarine areas of Southeast India. Excluding scientific knowledge of A. corniculatum against diabetes an upgrowing endocrinal disorder, our present study...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312728/ https://www.ncbi.nlm.nih.gov/pubmed/22470894 http://dx.doi.org/10.4103/2231-4040.93560 |
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author | Gurudeeban, S. Satyavani, K. Ramanathan, T. Balasubramanian, T. |
author_facet | Gurudeeban, S. Satyavani, K. Ramanathan, T. Balasubramanian, T. |
author_sort | Gurudeeban, S. |
collection | PubMed |
description | Earlier ethnopharmacological records divulged the traditional usages of mangrove Aegiceras corniculatum (Linn.) Blanco distributed in coastal and estuarine areas of Southeast India. Excluding scientific knowledge of A. corniculatum against diabetes an upgrowing endocrinal disorder, our present study evaluated the effect on alloxan-induced diabetic rats. Diabetes was induced in adult rats of the Wistar strain by intraperitoneal injection of alloxan monohydrate. The experimental rats were administered with leaf suspension of A. corniculatum post orally using an intragastric tube. On completion of the 60-day treatment, a range of biochemical parameters were tested including liver hexokinase, glucose-6phosphatase and fructose 1, 6 bisphosphatase in the liver of control and allaxon-diabetic rats. As a result, A. corniculatum leaf suspension showed moderate reduction in blood glucose (from 382 ± 34 to 105 ± 35), glycosylated hemoglobin, a decrease in the activities of glucose-6 phosphatase and fructose 1, 6-bisphosphatase, and an increase activity of liver hexokinase achieved through the oral administration of extract on 100 mg/kg. The present findings support promising results in terms of antidiabetic activities establishing its candidacy for further purification of individual compound in order to understand their mechanism of action. |
format | Online Article Text |
id | pubmed-3312728 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-33127282012-04-02 Antidiabetic effect of a black mangrove species Aegiceras corniculatum in alloxan-induced diabetic rats Gurudeeban, S. Satyavani, K. Ramanathan, T. Balasubramanian, T. J Adv Pharm Technol Res Original Article Earlier ethnopharmacological records divulged the traditional usages of mangrove Aegiceras corniculatum (Linn.) Blanco distributed in coastal and estuarine areas of Southeast India. Excluding scientific knowledge of A. corniculatum against diabetes an upgrowing endocrinal disorder, our present study evaluated the effect on alloxan-induced diabetic rats. Diabetes was induced in adult rats of the Wistar strain by intraperitoneal injection of alloxan monohydrate. The experimental rats were administered with leaf suspension of A. corniculatum post orally using an intragastric tube. On completion of the 60-day treatment, a range of biochemical parameters were tested including liver hexokinase, glucose-6phosphatase and fructose 1, 6 bisphosphatase in the liver of control and allaxon-diabetic rats. As a result, A. corniculatum leaf suspension showed moderate reduction in blood glucose (from 382 ± 34 to 105 ± 35), glycosylated hemoglobin, a decrease in the activities of glucose-6 phosphatase and fructose 1, 6-bisphosphatase, and an increase activity of liver hexokinase achieved through the oral administration of extract on 100 mg/kg. The present findings support promising results in terms of antidiabetic activities establishing its candidacy for further purification of individual compound in order to understand their mechanism of action. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3312728/ /pubmed/22470894 http://dx.doi.org/10.4103/2231-4040.93560 Text en Copyright: © Journal of Advanced Pharmaceutical Technology & Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Gurudeeban, S. Satyavani, K. Ramanathan, T. Balasubramanian, T. Antidiabetic effect of a black mangrove species Aegiceras corniculatum in alloxan-induced diabetic rats |
title | Antidiabetic effect of a black mangrove species Aegiceras corniculatum in alloxan-induced diabetic rats |
title_full | Antidiabetic effect of a black mangrove species Aegiceras corniculatum in alloxan-induced diabetic rats |
title_fullStr | Antidiabetic effect of a black mangrove species Aegiceras corniculatum in alloxan-induced diabetic rats |
title_full_unstemmed | Antidiabetic effect of a black mangrove species Aegiceras corniculatum in alloxan-induced diabetic rats |
title_short | Antidiabetic effect of a black mangrove species Aegiceras corniculatum in alloxan-induced diabetic rats |
title_sort | antidiabetic effect of a black mangrove species aegiceras corniculatum in alloxan-induced diabetic rats |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312728/ https://www.ncbi.nlm.nih.gov/pubmed/22470894 http://dx.doi.org/10.4103/2231-4040.93560 |
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