The chromosome 9 ALS and FTD locus is probably derived from a single founder

We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations. Here we show that the associated haplotype is the same in all populations and that several families previously shown to have...

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Autores principales: Mok, Kin, Traynor, Bryan J., Schymick, Jennifer, Tienari, Pentti J., Laaksovirta, Hannu, Peuralinna, Terhi, Myllykangas, Liisa, Chiò, Adriano, Shatunov, Aleksey, Boeve, Bradley F., Boxer, Adam L., DeJesus-Hernandez, Mariely, Mackenzie, Ian R., Waite, Adrian, Williams, Nigel, Morris, Huw R., Simón-Sánchez, Javier, van Swieten, John C., Heutink, Peter, Restagno, Gabriella, Mora, Gabriele, Morrison, Karen E., Shaw, Pamela J., Rollinson, Pamela Sara, Al-Chalabi, Ammar, Rademakers, Rosa, Pickering-Brown, Stuart, Orrell, Richard W., Nalls, Michael A., Hardy, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Genetic Reports Abstract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312749/
https://www.ncbi.nlm.nih.gov/pubmed/21925771
http://dx.doi.org/10.1016/j.neurobiolaging.2011.08.005
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author Mok, Kin
Traynor, Bryan J.
Schymick, Jennifer
Tienari, Pentti J.
Laaksovirta, Hannu
Peuralinna, Terhi
Myllykangas, Liisa
Chiò, Adriano
Shatunov, Aleksey
Boeve, Bradley F.
Boxer, Adam L.
DeJesus-Hernandez, Mariely
Mackenzie, Ian R.
Waite, Adrian
Williams, Nigel
Morris, Huw R.
Simón-Sánchez, Javier
van Swieten, John C.
Heutink, Peter
Restagno, Gabriella
Mora, Gabriele
Morrison, Karen E.
Shaw, Pamela J.
Rollinson, Pamela Sara
Al-Chalabi, Ammar
Rademakers, Rosa
Pickering-Brown, Stuart
Orrell, Richard W.
Nalls, Michael A.
Hardy, John
author_facet Mok, Kin
Traynor, Bryan J.
Schymick, Jennifer
Tienari, Pentti J.
Laaksovirta, Hannu
Peuralinna, Terhi
Myllykangas, Liisa
Chiò, Adriano
Shatunov, Aleksey
Boeve, Bradley F.
Boxer, Adam L.
DeJesus-Hernandez, Mariely
Mackenzie, Ian R.
Waite, Adrian
Williams, Nigel
Morris, Huw R.
Simón-Sánchez, Javier
van Swieten, John C.
Heutink, Peter
Restagno, Gabriella
Mora, Gabriele
Morrison, Karen E.
Shaw, Pamela J.
Rollinson, Pamela Sara
Al-Chalabi, Ammar
Rademakers, Rosa
Pickering-Brown, Stuart
Orrell, Richard W.
Nalls, Michael A.
Hardy, John
author_sort Mok, Kin
collection PubMed
description We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations. Here we show that the associated haplotype is the same in all populations and that several families previously shown to have genetic linkage to this region also share this haplotype. The most parsimonious explanation of these data are that there is a single founder for this form of disease.
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spelling pubmed-33127492013-01-01 The chromosome 9 ALS and FTD locus is probably derived from a single founder Mok, Kin Traynor, Bryan J. Schymick, Jennifer Tienari, Pentti J. Laaksovirta, Hannu Peuralinna, Terhi Myllykangas, Liisa Chiò, Adriano Shatunov, Aleksey Boeve, Bradley F. Boxer, Adam L. DeJesus-Hernandez, Mariely Mackenzie, Ian R. Waite, Adrian Williams, Nigel Morris, Huw R. Simón-Sánchez, Javier van Swieten, John C. Heutink, Peter Restagno, Gabriella Mora, Gabriele Morrison, Karen E. Shaw, Pamela J. Rollinson, Pamela Sara Al-Chalabi, Ammar Rademakers, Rosa Pickering-Brown, Stuart Orrell, Richard W. Nalls, Michael A. Hardy, John Neurobiol Aging Genetic Reports Abstract We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations. Here we show that the associated haplotype is the same in all populations and that several families previously shown to have genetic linkage to this region also share this haplotype. The most parsimonious explanation of these data are that there is a single founder for this form of disease. Elsevier 2012-01 /pmc/articles/PMC3312749/ /pubmed/21925771 http://dx.doi.org/10.1016/j.neurobiolaging.2011.08.005 Text en © 2012 Elsevier Inc. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Genetic Reports Abstract
Mok, Kin
Traynor, Bryan J.
Schymick, Jennifer
Tienari, Pentti J.
Laaksovirta, Hannu
Peuralinna, Terhi
Myllykangas, Liisa
Chiò, Adriano
Shatunov, Aleksey
Boeve, Bradley F.
Boxer, Adam L.
DeJesus-Hernandez, Mariely
Mackenzie, Ian R.
Waite, Adrian
Williams, Nigel
Morris, Huw R.
Simón-Sánchez, Javier
van Swieten, John C.
Heutink, Peter
Restagno, Gabriella
Mora, Gabriele
Morrison, Karen E.
Shaw, Pamela J.
Rollinson, Pamela Sara
Al-Chalabi, Ammar
Rademakers, Rosa
Pickering-Brown, Stuart
Orrell, Richard W.
Nalls, Michael A.
Hardy, John
The chromosome 9 ALS and FTD locus is probably derived from a single founder
title The chromosome 9 ALS and FTD locus is probably derived from a single founder
title_full The chromosome 9 ALS and FTD locus is probably derived from a single founder
title_fullStr The chromosome 9 ALS and FTD locus is probably derived from a single founder
title_full_unstemmed The chromosome 9 ALS and FTD locus is probably derived from a single founder
title_short The chromosome 9 ALS and FTD locus is probably derived from a single founder
title_sort chromosome 9 als and ftd locus is probably derived from a single founder
topic Genetic Reports Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312749/
https://www.ncbi.nlm.nih.gov/pubmed/21925771
http://dx.doi.org/10.1016/j.neurobiolaging.2011.08.005
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