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An Orthosteric Inhibitor of the Ras-Sos Interaction
Mimics of α-helices on protein surfaces have emerged as powerful reagents for antagonizing protein-protein interactions, which are difficult to target with small molecules. Herein we describe the design of a cell-permeable synthetic α-helix based on the guanine nucleotide exchange factor Sos that in...
Autores principales: | Patgiri, Anupam, Yadav, Kamlesh K., Arora, Paramjit S., Bar-Sagi, Dafna |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312813/ https://www.ncbi.nlm.nih.gov/pubmed/21765406 http://dx.doi.org/10.1038/nchembio.612 |
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