Cargando…

Synthesis, opioid receptor binding profile and SAR studies of 14-alkoxy-substituted indolo- and benzofuromorphinans

Detalles Bibliográficos
Autores principales:	Staaf, Alexander, Spetea, Mariana, Mittendorfer, Harald, Schmidhammer, Helmut
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Meeting Abstract
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3313220/ http://dx.doi.org/10.1186/1471-2210-8-S1-A30

Ejemplares similares

Influence of the 14-alkoxy group and the substitution in position 5 in N-methyl-14-alkoxymorphinan-6-ones on in vitro and in vivo pharmacological activities
por: Haddou, Tanila Ben, et al.
Publicado: (2012)

Biological, pharmacological and immunological activities of novel 6-amino-acid-substituted 14-alkoxy-N-methylmorphinans
por: Guerrieri, Elena, et al.
Publicado: (2011)

5-Benzyl substituted 14-methoxymetopon, a high affinity μ opioid receptor agonist with potent antinociceptive activity in mice
por: Spetea, Mariana, et al.
Publicado: (2008)

Development of novel N-methyl and N-allyl-substituted oxazolomorphinans and their interaction with opioid receptors
por: Sipos, Attila, et al.
Publicado: (2011)

A ligand-based 3D pharmacophore model for the μ opioid receptor: application to the morphinan class of opioids
por: Asim, Muhammad Faheem, et al.
Publicado: (2010)

Comparison of physicochemical properties and biological activities of opioid morphinans interacting with mu opioid receptors
por: Asim, Muhammad F, et al.
Publicado: (2008)

Development of 5-Substituted N-Methylmorphinan-6-ones as Potent Opioid Analgesics with Improved Side-Effect Profile
por: Schmidhammer, Helmut, et al.
Publicado: (2012)

Opioids and Their Receptors: Present and Emerging Concepts in Opioid Drug Discovery
por: Spetea, Mariana, et al.
Publicado: (2020)

Identification of novel ligands interacting with kappa opioid receptors
por: Spetea, Mariana, et al.
Publicado: (2011)

Introduction of a 6-cyano group in 14-oxygenated N-methylmorphinans influences in vitro and in vivo pharmacological activities
por: Follia, Valeria, et al.
Publicado: (2011)

Molecular Docking, Molecular Dynamics, and Structure–Activity Relationship Explorations of 14-Oxygenated N-Methylmorphinan-6-ones as Potent μ-Opioid Receptor Agonists
por: Noha, Stefan M., et al.
Publicado: (2017)

Discovery and biological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist
por: Spetea, Mariana, et al.
Publicado: (2012)

Synthesis and Pharmacological Activities of 6-Glycine Substituted 14-Phenylpropoxymorphinans, a Novel Class of Opioids with High Opioid Receptor Affinities and Antinociceptive Potencies
por: Spetea, Mariana, et al.
Publicado: (2011)

Recent Chemical and Pharmacological Developments on 14-Oxygenated-N-methylmorphinan-6-ones
por: Spetea, Mariana, et al.
Publicado: (2021)

Synthesis, Biological, and Structural Explorations of New Zwitterionic Derivatives of 14-O-Methyloxymorphone, as Potent μ/δ Opioid Agonists and Peripherally Selective Antinociceptives
por: Spetea, Mariana, et al.
Publicado: (2018)

Mechanistic Characterization of the Pharmacological Profile of HS-731, a Peripherally Acting Opioid Analgesic, at the µ-, δ-, κ-Opioid and Nociceptin Receptors
por: Puls, Kristina, et al.
Publicado: (2022)

In vitro and in vivo Pharmacological Activities of 14-O-Phenylpropyloxymorphone, a Potent Mixed Mu/Delta/Kappa-Opioid Receptor Agonist With Reduced Constipation in Mice
por: Lattanzi, Roberta, et al.
Publicado: (2018)

Development of Diphenethylamines as Selective Kappa Opioid Receptor Ligands and Their Pharmacological Activities
por: Schmidhammer, Helmut, et al.
Publicado: (2020)

In vitro and in vivo pharmacological profile of the 5-benzyl analogue of 14-methoxymetopon, a novel μ opioid analgesic with reduced propensity to alter motor function
por: Spetea, Mariana, et al.
Publicado: (2010)

N-Phenethyl Substitution in 14-Methoxy-N-methylmorphinan-6-ones Turns Selective µ Opioid Receptor Ligands into Dual µ/δ Opioid Receptor Agonists
por: Dumitrascuta, Maria, et al.
Publicado: (2020)

μ Opioid receptor: novel antagonists and structural modeling
por: Kaserer, Teresa, et al.
Publicado: (2016)

Pharmacological Investigations of N-Substituent Variation in Morphine and Oxymorphone: Opioid Receptor Binding, Signaling and Antinociceptive Activity
por: Ben Haddou, Tanila, et al.
Publicado: (2014)

Highly Potent and Selective New Diphenethylamines Interacting with the κ-Opioid Receptor: Synthesis, Pharmacology, and Structure–Activity Relationships
por: Erli, Filippo, et al.
Publicado: (2017)

Exploring pharmacological activities and signaling of morphinans substituted in position 6 as potent agonists interacting with the μ opioid receptor
por: Ben Haddou, Tanila, et al.
Publicado: (2014)

β-Amino- and Alkoxy-Substituted Disilanides
por: Balatoni, Istvan, et al.
Publicado: (2019)

Synthesis, Pharmacology, and Molecular Docking Studies on 6-Desoxo-N-methylmorphinans as Potent μ-Opioid Receptor Agonists
por: Dumitrascuta, Maria, et al.
Publicado: (2017)

Efficacy of systemic HS-198, an analogue of oxymorphone, on cancer pain-related behaviour in mice
por: Asim, Muhammad F, et al.
Publicado: (2011)

Unveiling 7-Hydroxymitragynine as the Key Active Metabolite of Mitragynine and the Promise for Creating Novel Pain Relievers
por: Spetea, Mariana, et al.
Publicado: (2019)

Bent and Twisted: Synthesis of an Alkoxy-Substituted (1,5)Naphthalene-paracyclophanediene
por: Mann, Arielle, et al.
Publicado: (2023)

Synthesis and Hydrogen‐Bond Patterns of Aryl‐Group Substituted Silanediols and ‐triols from Alkoxy‐ and Chlorosilanes
por: Kannengießer, Jan‐Falk, et al.
Publicado: (2021)

Alkoxy and Enediyne Derivatives Containing 1,4-Benzoquinone Subunits—Synthesis and Antitumor Activity
por: Kadela-Tomanek, Monika, et al.
Publicado: (2017)

Impact of Substitution Pattern and Chain Length on the Thermotropic Properties of Alkoxy-Substituted Triphenyl-Tristriazolotriazines †
por: Rieth, Thorsten, et al.
Publicado: (2020)

Synthesis and Photophysical and Electroluminescent Properties of Poly(1,4-phenylene–ethynylene)-alt-poly(1,4-phenylene–vinylene)s with Various Dissymmetric Substitution of Alkoxy Side Chains
por: Bouguerra, Nassima, et al.
Publicado: (2016)

Peripheralization Strategies Applied to Morphinans and Implications for Improved Treatment of Pain
por: Schmidhammer, Helmut, et al.
Publicado: (2023)

The Influence of Alkoxy Substitutions on the Properties of Diketopyrrolopyrrole-Phenyl Copolymers for Solar Cells
por: George, Zandra, et al.
Publicado: (2013)

Synthesis and Molecular Docking Studies of Alkoxy- and Imidazole-Substituted Xanthones as α-Amylase and α-Glucosidase Inhibitors
por: Aguila-Muñoz, Dolores G., et al.
Publicado: (2023)

Synthesis of C2-Alkoxy-Substituted 19-Nor Vitamin D(3) Derivatives: Stereoselectivity and Biological Activity
por: Mizumoto, Yuka, et al.
Publicado: (2022)

Synthesis of substituted 15β-alkoxy estrone derivatives and their cofactor-dependent inhibitory effect on 17β-HSD1
por: Herman, Bianka Edina, et al.
Publicado: (2019)

Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacy
por: Filak, Lukas K., et al.
Publicado: (2010)

Receptor Interaction Profiles of 4-Alkoxy-Substituted 2,5-Dimethoxyphenethylamines and Related Amphetamines
por: Kolaczynska, Karolina E., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_of4f40c326dvpc3m6r84g1to2m