Cargando…
Trypanosomatid comparative genomics: Contributions to the study of parasite biology and different parasitic diseases
In 2005, draft sequences of the genomes of Trypanosoma brucei, Trypanosoma cruzi and Leishmania major, also known as the Tri-Tryp genomes, were published. These protozoan parasites are the causative agents of three distinct insect-borne diseases, namely sleeping sickness, Chagas disease and leishman...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Genética
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3313497/ https://www.ncbi.nlm.nih.gov/pubmed/22481868 |
_version_ | 1782228002443100160 |
---|---|
author | Teixeira, Santuza M. de Paiva, Rita Márcia Cardoso Kangussu-Marcolino, Monica M. DaRocha, Wanderson D. |
author_facet | Teixeira, Santuza M. de Paiva, Rita Márcia Cardoso Kangussu-Marcolino, Monica M. DaRocha, Wanderson D. |
author_sort | Teixeira, Santuza M. |
collection | PubMed |
description | In 2005, draft sequences of the genomes of Trypanosoma brucei, Trypanosoma cruzi and Leishmania major, also known as the Tri-Tryp genomes, were published. These protozoan parasites are the causative agents of three distinct insect-borne diseases, namely sleeping sickness, Chagas disease and leishmaniasis, all with a worldwide distribution. Despite the large estimated evolutionary distance among them, a conserved core of ~6,200 trypanosomatid genes was found among the Tri-Tryp genomes. Extensive analysis of these genomic sequences has greatly increased our understanding of the biology of these parasites and their host-parasite interactions. In this article, we review the recent advances in the comparative genomics of these three species. This analysis also includes data on additional sequences derived from other trypanosmatid species, as well as recent data on gene expression and functional genomics. In addition to facilitating the identification of key parasite molecules that may provide a better understanding of these complex diseases, genome studies offer a rich source of new information that can be used to define potential new drug targets and vaccine candidates for controlling these parasitic infections. |
format | Online Article Text |
id | pubmed-3313497 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Sociedade Brasileira de Genética |
record_format | MEDLINE/PubMed |
spelling | pubmed-33134972012-04-05 Trypanosomatid comparative genomics: Contributions to the study of parasite biology and different parasitic diseases Teixeira, Santuza M. de Paiva, Rita Márcia Cardoso Kangussu-Marcolino, Monica M. DaRocha, Wanderson D. Genet Mol Biol Review Article In 2005, draft sequences of the genomes of Trypanosoma brucei, Trypanosoma cruzi and Leishmania major, also known as the Tri-Tryp genomes, were published. These protozoan parasites are the causative agents of three distinct insect-borne diseases, namely sleeping sickness, Chagas disease and leishmaniasis, all with a worldwide distribution. Despite the large estimated evolutionary distance among them, a conserved core of ~6,200 trypanosomatid genes was found among the Tri-Tryp genomes. Extensive analysis of these genomic sequences has greatly increased our understanding of the biology of these parasites and their host-parasite interactions. In this article, we review the recent advances in the comparative genomics of these three species. This analysis also includes data on additional sequences derived from other trypanosmatid species, as well as recent data on gene expression and functional genomics. In addition to facilitating the identification of key parasite molecules that may provide a better understanding of these complex diseases, genome studies offer a rich source of new information that can be used to define potential new drug targets and vaccine candidates for controlling these parasitic infections. Sociedade Brasileira de Genética 2012 2012-01-20 /pmc/articles/PMC3313497/ /pubmed/22481868 Text en Copyright © 2012, Sociedade Brasileira de Genética. Printed in Brazil License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Teixeira, Santuza M. de Paiva, Rita Márcia Cardoso Kangussu-Marcolino, Monica M. DaRocha, Wanderson D. Trypanosomatid comparative genomics: Contributions to the study of parasite biology and different parasitic diseases |
title | Trypanosomatid comparative genomics: Contributions to the study of parasite biology and different parasitic diseases |
title_full | Trypanosomatid comparative genomics: Contributions to the study of parasite biology and different parasitic diseases |
title_fullStr | Trypanosomatid comparative genomics: Contributions to the study of parasite biology and different parasitic diseases |
title_full_unstemmed | Trypanosomatid comparative genomics: Contributions to the study of parasite biology and different parasitic diseases |
title_short | Trypanosomatid comparative genomics: Contributions to the study of parasite biology and different parasitic diseases |
title_sort | trypanosomatid comparative genomics: contributions to the study of parasite biology and different parasitic diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3313497/ https://www.ncbi.nlm.nih.gov/pubmed/22481868 |
work_keys_str_mv | AT teixeirasantuzam trypanosomatidcomparativegenomicscontributionstothestudyofparasitebiologyanddifferentparasiticdiseases AT depaivaritamarciacardoso trypanosomatidcomparativegenomicscontributionstothestudyofparasitebiologyanddifferentparasiticdiseases AT kangussumarcolinomonicam trypanosomatidcomparativegenomicscontributionstothestudyofparasitebiologyanddifferentparasiticdiseases AT darochawandersond trypanosomatidcomparativegenomicscontributionstothestudyofparasitebiologyanddifferentparasiticdiseases |