TXNIP Links Innate Host Defense Mechanisms to Oxidative Stress and Inflammation in Retinal Muller Glia under Chronic Hyperglycemia: Implications for Diabetic Retinopathy

Thioredoxin Interacting Protein (TXNIP) mediates retinal inflammation, gliosis, and apoptosis in experimental diabetes. Here, we investigate the temporal response of Muller glia to high glucose (HG) and TXNIP expression using a rat Muller cell line (rMC1) in culture. We examined if HG-induced TXNIP...

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Detalles Bibliográficos
Autores principales: Devi, Takhellambam S., Lee, Icksoo, Hüttemann, Maik, Kumar, Ashok, Nantwi, Kwaku D., Singh, Lalit P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3313582/
https://www.ncbi.nlm.nih.gov/pubmed/22474421
http://dx.doi.org/10.1155/2012/438238

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